文献类型：期刊文献

中文题名：虎梅止泻冲剂药效学研究

英文题名：Study on Delaying Action of Angelica Injection on Muscle Atrophy after Sciatic Nerve Injury

作者：任远[1];崔祝梅[1];马骏[1];黄正良[1];杨峰[2];边英梅[2]

第一作者：任远

机构：[1]甘肃中医学院;[2]甘肃省河西制药厂

第一机构：甘肃中医药大学

年份：1997

卷号：19

期号：4

起止页码：27

中文期刊名：中成药

外文期刊名：CHINESE TRADITIONAL PATENT MEDICINE

收录：CSTPCD;;CSCD:【CSCD2011_2012】；

语种：中文

中文关键词：虎梅止泻冲剂;中药药理学

外文关键词：Radix Angelicae Sinensis, sciatic nerve injury,muscle atrophy

摘要：虎梅止泻冲剂对家兔离体十二指肠自发活动，小鼠小肠推进运动和大鼠大肠推进运动均呈抑制作用；能明显对抗乙酰胆碱、氯化钡、组胺引起的高体肠肌收缩；对抗大黄的泻下作用；对鼠伤寒沙门氏菌有抗菌作用：还可增强小鼠腹腔巨噬细胞吞噬功能。
In order to investigate whether Radix Angelicae Sinensis delays the muscle atrophy or not, we used a model with the second degree of Seddon injury classification for rat' s sciatic nerve and performed Radix Angelicae Sinensis therapy. We measured the weight of extensor digitorum longus muscles and the concentration of both the malondialdehyde (MDA) and superoxide dismutase (SOD). The results showed that Radix Angelicae Sinensis can delay the muscle atrophy significantly and increased the MDA and SOD in the muscle tissues.Perhaps its application promoted the muscular blood circulation and enhanced their metabolism.