文献类型：期刊文献

英文题名：Association between splenectomy and chronic thromboembolic pulmonary hypertension: a systematic review and meta-analysis

作者：Zhang, Liyan[1,2,3,4];Yan, Peijing[5,6];Yang, Kehu[3,4,7];Wu, Shanlian[8];Bai, Yuping[1];Zhu, Xinyu[9];Chen, Xiaojie[9];Li, Li[9];Cao, Yunshan[10];Zhang, Min[2]

第一作者：Zhang, Liyan;张陆阳;张莉云;张利英

通信作者：Zhang, M[1];Cao, YS[2]

机构：[1]Gansu Univ Chinese Med, Sch Basic Med, Lanzhou, Gansu, Peoples R China;[2]Gansu Prov Hosp, Dept Pathol, Lanzhou, Gansu, Peoples R China;[3]Lanzhou Univ, Gansu Prov Hosp, Inst Clin Res & Evidence Based Med, Lanzhou, Gansu, Peoples R China;[4]Lanzhou Univ, Evidence Based Med Ctr, Lanzhou, Gansu, Peoples R China;[5]Sichuan Univ, West China Sch Publ Hlth, Dept Epidemiol & Hlth Stat, Chengdu, Sichuan, Peoples R China;[6]Sichuan Univ, West China Hosp 4, Chengdu, Sichuan, Peoples R China;[7]Key Lab Evidence Based Med & Knowledge Translat G, Lanzhou, Gansu, Peoples R China;[8]Ganzhou Peoples Hosp, Dept Pathol, Ganzhou, Jiangxi, Peoples R China;[9]Gansu Prov Hosp, Dept Sci & Res, Lanzhou, Gansu, Peoples R China;[10]Gansu Prov Hosp, Dept Cardiol, Lanzhou, Gansu, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Prov Hosp, Dept Pathol, Lanzhou, Gansu, Peoples R China;[2]corresponding author), Gansu Prov Hosp, Dept Cardiol, Lanzhou, Gansu, Peoples R China.

年份：2021

卷号：11

期号：2

外文期刊名：BMJ OPEN

收录：;Scopus(收录号：2-s2.0-85101578948);WOS:【SCI-EXPANDED(收录号:WOS:000623282300023)】；

基金：This study was supported by the National Natural Science Foundation of China (grant no 81860059), the International Cooperation Exchange Project of Gansu Province (grant no 18YF1WA046), and CAS 'Light of West China' programme granted to MZ and YC.

语种：英文

外文关键词：respiratory physiology; adult surgery; adult thoracic medicine

摘要：Objective Whether splenectomy increases the risk of chronic thromboembolic pulmonary hypertension (CTEPH) remains unclear. We conducted a systematic review and meta-analysis to explore the association between splenectomy and CTEPH. Design Systematic review and meta-analysis. Data sources PubMed, Embase and Cochrane Library databases. Methods Two authors independently searched and extracted the data. The Newcastle-Ottawa Scale and the Strengthening the Reporting of Observational Studies in Epidemiology guidelines were used to assess the quality of the included studies, and each quality item was graded as low risk or high risk. A random-effects model was used to calculate different effective values. Results In total, 8 trials involving 6183 participants fulfilled the inclusion criteria. The overall pooled crude prevalence of splenectomy was 4.0% (95% CI 0.03 to 0.06, I-2=71.5%, p<0.001) in patients with CTEPH. Subgroup analysis showed a statistically significant high incidence of splenectomy in patients with CTEPH (OR=2.94, 95% CI 1.62 to 5.33, I-2=0.0%, p<0.001) compared with patients with pulmonary arterial hypertension. There was a significantly high incidence of splenectomy in patients with CTEPH (OR=5.59, 95% CI 2.12 to 14.74, I-2=0.0%, p<0.001) compared with patients with thromboembolism disease (venous thromboembolism or pulmonary embolism). Conclusion The prevalence of splenectomy in patients with CTEPH was 4.0% and CTEPH might be associated with splenectomy. However, high-quality prospective trials are needed. PROSPERO registration number CRD42020137591.