文献类型：期刊文献

中文题名：头痛安的镇痛作用及对大鼠血液流变学的影响

英文题名：Analgesic action of Toutongan and its effect on hemorheology in rats

作者：顾静[1];李海龙[1];吴国泰[1];王虎平[1];车敏[1];杨子宜[1];赵炳辰[1];吴红彦[1]

第一作者：顾静

机构：[1]甘肃中医药大学

第一机构：甘肃中医药大学

年份：2019

卷号：35

期号：3

起止页码：117

中文期刊名：中药药理与临床

外文期刊名：Pharmacology and Clinics of Chinese Materia Medica

收录：北大核心:【北大核心2017】；CSCD:【CSCD2019_2020】；

基金：甘肃省科技重大专项计划(1203FKDA029)

语种：中文

中文关键词：头痛安;偏头痛;血液流变学;活血化瘀

外文关键词：Migraine;Toutongan;hemorheology;Huoxuehuayu

摘要：目的:考察头痛安的镇痛作用及对血瘀模型大鼠血液流变学的影响。方法:采用皮下注射硝酸甘油或者肾上腺素结合冰水浸泡分别诱发偏头痛大鼠模型和血瘀大鼠模型,并予头痛安滴鼻干预,从行为学药效指标和血液流变学指标两个方面观察头痛安对偏头痛模型大鼠的影响。结果:对比空白对照组,模型组大鼠有明显的耳红、挠头、爬笼等偏头痛的行为学症状,同时在不同切变率下的全血及其还原粘度、血浆、血清和纤维蛋白原粘度、红细胞压积、血小板聚集电阻值均增高;对比模型组,阿司匹林0.3 g/kg组和头痛安0.84 g/kg、1.68 g/kg剂量组大鼠耳红和挠头的消失时间缩短,在30 min^180 min内各个时间段的挠头次数和爬笼次数减少,显著逆转了上述异常的血液流变学指标,尤以1.68 g/kg头痛安效应最显著。结论:大鼠皮下注射硝酸甘油能有效诱发出偏头痛行为学症状,头痛安能降低血瘀模型大鼠的血液粘滞度相关指标、减小红细胞压积及血小板聚集电阻值,有效改善血瘀大鼠血液高粘滞性和高聚集性的血液流变学指标,头痛安防治偏头痛作用与"活血化瘀"功效有关。
Objective:To investigate the analgesic action of "Toutongan" and its effect on blood hemorheology in Xueyu rat model. Methods: Methods of " subcutaneous injection of nitroglycerin(GNT) or adrenaline(Adr) combined with soaked in ice water" were used to establish the Xueyu model and migraine rat model, respectively. After treated with Toutongan nasal inhalation, indexes of behavioristics and hemorheology were observed. Results:Compared with the control group, behavioral symptoms of migraine such as ear red, scratching head and climbing cage were observed in the model group, hemorheology indexes such as blood viscosity, plasma viscosity, serum viscosity, fibrinogen viscosity, hematokrit and Platelet aggregation resistance were increased. Compared with the model group, migraine behavioral symptoms such as ear red and scratching head were observed absent faster in 3 g/kg aspirin group and Toutongan groups(0.84 g/kg、1.68 g/kg), numbers of scratching head and climbing cage were decreased during 30~180 min periods. The changing hemorheology indexes were significantly reversed, especially in 1.68 g/kg Toutongan group.Conclusion:"Subcutaneous injection of nitroglycerin" may effectively induce migraine behavioral symptoms. In blood stasis rat model, Toutongan can reduce the related indexes of blood viscosity, hematokrit and Platelet aggregation resistance value. Its effect on migraine may be related to "Huoxuehuayu" in TCM.