文献类型：期刊文献

英文题名：Recent advances in characterizing the immune microenvironment and biomarkers of endometrial carcinoma

作者：Ma, Jianhong[1];Yao, Guang[2];Wang, Wei[1]

第一作者：Ma, Jianhong

通信作者：Wang, W[1];Yao, G[2]

机构：[1]Gansu Univ Chinese Med, Gynecol Affiliated Hosp, Dept Obstet, Lanzhou, Peoples R China;[2]Lanzhou Univ, Hosp 1, Dept Obstet & Gynecol, Lanzhou, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Gynecol Affiliated Hosp, Dept Obstet, Lanzhou, Peoples R China;[2]corresponding author), Lanzhou Univ, Hosp 1, Dept Obstet & Gynecol, Lanzhou, Peoples R China.|[10735]甘肃中医药大学;

年份：2026

卷号：17

外文期刊名：FRONTIERS IN IMMUNOLOGY

收录：;Scopus(收录号：2-s2.0-105042930921);WOS:【SCI-EXPANDED(收录号:WOS:001791130100001)】；

基金：The author(s) declared that financial support was received for this work and/or its publication. The Construction Project of Gansu Provincial Traditional Chinese Medicine (TCM) Regional Women and Children Healthcare Center (Document No. 4, Gansu Provincial Administration of TCM, 2025), Gansu Provincial Specialized Construction Project for TCM-Integrated Gynecology (Document No. 7, Gansu Provincial Administration of TCM, 2024), and Gansu Provincial TCM Gynecology Excellence Alliance Program-Phase I (Document No. 14, Gansu Provincial Administration of TCM, 2025).

语种：英文

外文关键词：biomarker; endometrial carcinoma; immune cell; immune microenvironment; prediction model; risk score

摘要：This study builds upon existing research achievements in bioinformatics to systematically screen a comprehensive set of biomarkers and prognostic models associated with immune infiltration regulation in the tumor microenvironment of endometrial carcinoma. It elucidates the predictive value of these markers and models as well as the oncogenic signaling pathways in which they are involved, thereby providing a theoretical foundation and molecular insights into the characteristics of tumor immune infiltration in endometrial carcinoma. Through a cross-study analysis, five immune-related markers and two gene families consistently reported across multiple investigations were identified. Their clinical prognostic significance was validated, and potential mechanisms underlying their roles in carcinogenesis were proposed. Furthermore, the functional implications of immune infiltrating cells on tumor behavior are summarized, offering valuable guidance for target identification and therapeutic strategy development in future clinical immunopharmacological research.