文献类型：期刊文献

中文题名：基于炎症学说探讨巨噬细胞极化与骨质疏松症相关性

英文题名：Discussion on Relationship between Macrophage Polarization and Osteoporosis Based on Inflammation Theory

作者：马晨光[1];杨青峰[1];于继凯[1];周玉英[2];蒋宜伟[1,2]

第一作者：马晨光

机构：[1]甘肃中医药大学中医临床学院,甘肃兰州730101;[2]甘肃中医药大学附属医院,甘肃兰州730020

第一机构：甘肃中医药大学中医临床学院

年份：2022

卷号：40

期号：11

起止页码：114

中文期刊名：中华中医药学刊

外文期刊名：Chinese Archives of Traditional Chinese Medicine

收录：CSTPCD;;北大核心:【北大核心2020】；

基金：国家自然科学基金地区基金(82160916);甘肃省自然科学基金(1010RJZA160);甘肃省中医药管理局基金(GZK-2017-17);兰州市科技计划(2021-1-95)。

语种：中文

中文关键词：炎症学说;巨噬细胞极化;骨质疏松症;综述

外文关键词：inflammation doctrine;macrophage polarization;osteoporosis;review

摘要：骨质疏松症(osteoporosis, OP)是一种由于骨量丢失、骨微观结构破坏而易骨折的进行性骨病,其发病机制仍未被完全阐释清楚。有关研究表明,慢性炎症是导致骨质疏松症发展的重要原因之一,尤其是巨噬细胞极化诱导的慢性炎症,巨噬细胞极化过程中大量炎症因子通过调控相关衍生物合成,打破成骨细胞与破骨细胞之间的平衡性,影响骨质疏松症的发生发展。基于炎症学说对巨噬细胞极化与骨质疏松症相关性的具体机制作用进行简要综述,旨在为骨质疏松症相关分子机制研究提供新思路。
Objective Osteoporosis is a progressive bone disease that is prone to fracture due to loss of bone mass and destruction of bone microstructure,and its pathogenesis has not been fully explained.Related studies have shown that chronic inflammation is one of the important cause leading to the development of osteoporosis,especially chronic inflammation induced by macrophage polarization.In the process of macrophage polarization,a large number of inflammatory factors break the balance between osteoblasts and osteoclasts by regulating the synthesis of related derivatives and affect the occurrence and development of osteoporosis.Based on inflammation theory,this paper briefly reviewed the specific mechanism of macrophage polarization and osteoporosis,aiming to provide new ideas for the study of osteoporosis related molecular mechanism.