文献类型：期刊文献

英文题名：Pin1: Advances in pancreatic cancer therapeutic potential and inhibitors research

作者：Wang, Nan[1,2,3];Chai, Tian[2,3];Wang, Xing-Rong[2,3];Zheng, Yi-Dan[2,3];Sang, Chun-Yan[2,3];Yang, Jun-Li[1,2,3]

第一作者：王楠;Wang, Nan

通信作者：Sang, CY[1];Yang, JL[1];Sang, CY[2];Yang, JL[2]

机构：[1]Gansu Univ Chinese Med, Coll Pharm, Lanzhou, Peoples R China;[2]Chinese Acad Sci, CAS Key Lab Chem Northwestern Plant Resources, Lanzhou 730000, Peoples R China;[3]Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Nat Med Gansu Prov, Lanzhou 730000, Peoples R China

第一机构：甘肃中医药大学药学院（西北中藏药协同创新中心办公室）

通信机构：[1]corresponding author), Chinese Acad Sci, CAS Key Lab Chem Northwestern Plant Resources, Lanzhou 730000, Peoples R China;[2]corresponding author), Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Nat Med Gansu Prov, Lanzhou 730000, Peoples R China.

年份：2024

卷号：153

外文期刊名：BIOORGANIC CHEMISTRY

收录：;Scopus(收录号：2-s2.0-85206243300);WOS:【SCI-EXPANDED(收录号:WOS:001338662100001)】；

基金：This work was supported by the National Natural Science Foundation of China (No.32161143019), International Partnership Program of Chinese Academy of Sciences (No.E304G6GH), Science and Technology Program of Gansu Province (23ZDNA002, 23ZYQK0001 and 23JRRA623), Science and Technology Program of Sichuan Province (2022YFN0019), the scientific research program of Longnan City (2022-SQKJ-03 and 2022-SQKJ-05), and the scientific research program of Qingdao City (23-1-3-13-zyyd-nsh), Major Program of the Lanzhou Institute of Chemical Physics, CAS (ZYFZFX-6). Schematic figures were drawn by Figdraw (www.figdraw.com).

语种：英文

外文关键词：Pancreatic cancer; Peptidyl-prolyl cis/trans isomerase NIMA-; interaction 1; Tumor microenvironment; Hypoxic microenvironment; Pin1 inhibitors

摘要：The peptidyl-prolyl cis/trans isomerase NIMA-interaction 1 (Pin1) catalyzes the transition of the proline ring from the cis to trans conformation, resulting in conformational and functional changes in proteins that are regulated by proline-guided serine/threonine phosphorylation. In recent years, Pin1 has emerged as a novel molecular target for the diagnosis and treatment of various malignant tumors. Notably, it has been found that Pin1 is highly expressed in pancreatic cancer. This article focuses on the mechanisms by which Pin1 orchestrates multiple oncogenic functions in the development of pancreatic cancer. By exploring the intricate interactions between Pin1 and the pancreatic tumor microenvironment, we provide an overview of Pin1 ' s role in modifying glycolytic metabolism, redox balance, and the hypoxic microenvironment of pancreatic cancer. Furthermore, we summarize the potential anticancer effects of Pin1 inhibitors, aiming to elucidate Pin1 ' s promise as a potential anticancer agent, particularly in the context of pancreatic cancer.