文献类型：期刊文献

中文题名：中药药对治疗偏头痛机制及应用研究进展

英文题名：Research progress on mechanisms and applications of Chinese herbal pairs in treatment of migraine

作者：包璇[1];金华[1];张泽祥[1];刘杰[1];杜婕[1];雍芸[1]

第一作者：包璇

机构：[1]甘肃中医药大学中医临床学院,甘肃兰州730000

第一机构：甘肃中医药大学中医临床学院

年份：2025

卷号：56

期号：16

起止页码：6006

中文期刊名：中草药

外文期刊名：Chinese Traditional and Herbal Drugs

收录：;北大核心:【北大核心2023】；

基金：国家自然科学基金资助项目(82160886);甘肃省省级重点人才项目(2023RCXM28);甘肃省省级科技计划项目(23JRRA1524)。

语种：中文

中文关键词：偏头痛;中药药对;川芎-白芷;桂枝-白芍;天麻-钩藤

外文关键词：migraine;Chinese herb pairs;Chuanxiong Rhizoma-Angelicae Dahuricae Radix;Cinnamomi Ramulus-Paeoniae Radix Alba;Gastrodiae Rhizoma-Uncariae Ramulus Cum Uncis

摘要：偏头痛是一种复杂的神经系统疾病,其全球发病率和患病率逐年持续攀升,已成为当代社会不容忽视的公共卫生问题。在传统中医药体系中,中药药对作为中药配伍中最小的单位及复方配伍的基本组成部分,在偏头痛的预防和治疗领域展现出独特的临床优势。基于此,根据中国知网数据库中收录的有关中药药对抗偏头痛药理作用机制及应用相关文献,通过深度分析筛选、系统归纳梳理出4类典型药对,包括祛风解表类、平肝息风类、活血化瘀类、益气养血类。现代药理表明,这些药对通过多靶点、多途径协同作用机制发挥显著的抗偏头痛效应。不仅为临床精准用药提供了循证依据,也为传统药对开发新型抗偏头痛药物提供了重要的理论基础。
Migraine is a complex neurological disorder with a globally increasing incidence and prevalence year by year,which has become a public health issue that cannot be ignored in contemporary society.In traditional Chinese medicine system,Chinese herbal pairs,as the smallest unit in Chinese medicine compatibility and the basic component of compound prescriptions,have shown unique clinical advantages in the prevention and treatment of migraine.Based on this,according to the literature on the pharmacological mechanism and application of Chinese herbal pairs against migraine included in CNKI database,through in-depth analysis,screening,and systematic induction,four types of typical herbal pairs are sorted out,including those for dispelling wind and relieving exterior syndrome,calming the liver and extinguishing wind,promoting blood circulation and removing blood stasis,and replenishing qi and nourishing blood.Modern pharmacology has shown that these herbal pairs exert significant anti-migraine effects through a multi-target and multi-pathway synergistic mechanism.They not only provide evidence-based basis for precise clinical medication but also lay an important theoretical foundation for the development of new anti-migraine drugs from traditional herbal pairs.