文献类型：期刊文献

英文题名：15-PGDH Expression in Gastric Cancer: A Potential Role in Anti-Tumor Immunity

作者：Li, Yaling[1,2,3];Li, Junjie[1];Dong, Juanjuan[1];Zhang, Lei[2];Liu, Donglin[1,4];He, Jianzheng[1,2,3];She, Yali[2];Ma, Chengxu[2];Liu, Yongqi[1,2,3]

第一作者：李亚玲;Li, Yaling

通信作者：Liu, YQ[1]

机构：[1]Gansu Univ Chinese Med, Prov Level Key Lab Mol Med Major Dis & Study Prev, 35 Dingxi East Rd, Lanzhou 730000, Gansu, Peoples R China;[2]Gansu Univ Chinese Med, Basic Med Coll, Lanzhou, Gansu, Peoples R China;[3]Chinese Minist Educ & Gansu Prov, Key Lab Dunhuang Med & Transformat, Lanzhou, Gansu, Peoples R China;[4]Gansu Univ Chinese Med, Coll Pharm, Lanzhou, Gansu, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Prov Level Key Lab Mol Med Major Dis & Study Prev, 35 Dingxi East Rd, Lanzhou 730000, Gansu, Peoples R China.|[10735]甘肃中医药大学;

年份：2020

卷号：12

起止页码：7419

外文期刊名：CANCER MANAGEMENT AND RESEARCH

收录：;Scopus(收录号：2-s2.0-85089837932);WOS:【SCI-EXPANDED(收录号:WOS:000564199100001)】；

基金：This study was supported by the National Natural Science Foundation of China (No. 81960869); the Foundation of Key Laboratory of Dunhuang Medicine and Transformation Constructed by Chinese Ministry of Education and Gansu Province (No. DHYX18-12); and the Youth Research Foundation of the Gansu University of Chinese Medicine (No. ZQ2017-2).

语种：英文

外文关键词：gastric cancer; 15-PGDH; immunosuppression; FOXP3; Tregs

摘要：Introduction: Host immunity plays a vital role in tumorigenesis, including in tumor invasion and metastasis. However, the precise underlying mechanism remains to be explored. The enzyme 15-PGDH, which plays a key role in prostaglandin degradation, is a critical inflammatory mediator in gastric cancer (GC) tumorigenesis. Materials and Methods: Immunohistochemistry was performed to determine 15-PGDH expression in GC and the corresponding adjacent non-neoplastic tissues (n=92). Results: The expression of 15-PGDH in GC tissues was significantly lower than that in paracancerous tissues (P<0.001) and found to correspond inversely with GC differentiation (P=0.043) and lymph node metastasis (P=0.046). In contrast, FOXP3 expression was increased in poorly differentiated GC tissues (P=0.001). Kaplan Meier analysis revealed that GC patients with low expression of 15-PGDH (Log rank test, P=0.007) and high expression of FOXP3 (Log rank test, P=0.009) had shorter overall survival (OS) than those with high 15-PGDH and low FOXP3 expression. OS was also correlated with pathological tumor-node-metastasis stage (Log rank test, P=0.014). Furthermore, using Cox proportional hazard regression, 15-PGDH expression [hazard ratio (HR): 0.605 (0.440-0.833); P=0.002] was identified as an independent factor for OS. Conclusion: Our data suggest that 15-PGDH may contribute to anti-tumor immunity by regulating FOXP3(+) Treg cells. The findings are useful for the identification of therapeutic targets for the management of GC.