文献类型：期刊文献

英文题名：Prognostic value of the FBG/HDL-C ratio for 28-day all-cause mortality in critically ill patients: a retrospective cohort study with external validation

作者：Xiang, Xiao-jun[1,2,3];Ma, Li[1,4];Sun, Xiao-long[5];Ma, Dong-yu[5];Liu, Meng-yang[5];Li, Jian-feng[2];Zhang, Wen-bo[1];Xie, Ping[1,2,5]

第一作者：Xiang, Xiao-jun

通信作者：Xie, P[1];Xie, P[2];Xie, P[3]

机构：[1]Gansu Univ Chinese Med, Sch Tradit Chinese & Western Med, Lanzhou 730000, Peoples R China;[2]Natl Clin Res Ctr Cardiovasc Dis, Gansu Prov Hosp, Dept Cardiovasc Med, Branch Construct Unit, Lanzhou 730000, Peoples R China;[3]Chongqing Three Gorges Med Coll, Dept Resp & Crit Care Med, Affiliated Fengjie Hosp, Chongqing 404600, Fengjie, Peoples R China;[4]Gansu Matern & Child Hlth Care Hosp, Gansu Cent Hosp, Dept Geriatr, Lanzhou 730000, Peoples R China;[5]Gansu Univ Chinese Med, Clin Med Coll 1, Lanzhou 730000, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Sch Tradit Chinese & Western Med, Lanzhou 730000, Peoples R China;[2]corresponding author), Natl Clin Res Ctr Cardiovasc Dis, Gansu Prov Hosp, Dept Cardiovasc Med, Branch Construct Unit, Lanzhou 730000, Peoples R China;[3]corresponding author), Gansu Univ Chinese Med, Clin Med Coll 1, Lanzhou 730000, Peoples R China.|[10735]甘肃中医药大学;

年份：2026

卷号：31

期号：1

外文期刊名：EUROPEAN JOURNAL OF MEDICAL RESEARCH

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001735288500005)】；

基金：This work was supported by the National Natural Science Foundation of China (Grant No. 82460051) and the Major Project of Gansu Province Joint Research Fund (Grant No. 24JRRA886).

语种：英文

外文关键词：Critical illness; Metabolic stress; FBG/HDL-C ratio; Short-term mortality; Mediation analysis

摘要：BackgroundMetabolic dysregulation in critical illness may involve early changes in early morning fasting blood glucose (FBG) and high-density lipoprotein cholesterol (HDL-C), but the prognostic value of combining these measures is unclear.MethodsWe analyzed adult ICU patients from MIMIC-IV (v3.1) with FBG (03:00-07:59) and HDL-C measured within 24 h of admission. Using multivariable Cox models, we assessed the association between the FBG/HDL-C ratio and 28-day all-cause mortality, examining nonlinear effects via restricted cubic splines and exploratory mediation by white blood cell count (WBC) and blood-urea-nitrogen (BUN). Findings were externally validated in the eICU database.ResultsElevated FBG/HDL-C ratios were independently associated with 28-day all-cause mortality, with a nonlinear threshold identified at 5.934 and an AUC of 0.773. This association may be partially mediated by systemic inflammation and renal impairment.ConclusionsAmong critically ill patients with available FBG and HDL-C measurements, the FBG/HDL-C ratio was independently associated with short-term mortality, suggesting its potential as a supplementary risk stratification tool-though generalizability is limited by nonroutine HDL-C testing.