文献类型：期刊文献

中文题名：皂角刺抗肿瘤药理作用及化学成分研究进展

英文题名：Antineoplastic pharmacological effects of Gleditsiae spina

作者：李文基[1];马骏[1,2];赵文秀[1]

第一作者：李文基

机构：[1]甘肃中医药大学药学院,甘肃兰州730101;[2]国家中医药管理局中医药科研三级实验室中药药理实验室,甘肃兰州730000

第一机构：甘肃中医药大学药学院（西北中藏药协同创新中心办公室）

年份：2020

卷号：37

期号：6

起止页码：85

中文期刊名：甘肃中医药大学学报

外文期刊名：Journal of Gansu University of Chinese Medicine

语种：中文

中文关键词：皂角刺;抗肿瘤;药理作用;化学成分;研究进展

外文关键词：Gleditsiae spina;antineoplastic;pharmacological effects;chemical constituents;research progress

摘要：通过检索有关皂角刺化学成分和药理作用、药效研究的相关文献,对其抗肿瘤药理作用及化学成分的研究进行整理,并作一简要概述,为进一步研究皂角刺的抗肿瘤作用提供参考。通过总结发现,皂角刺抗肿瘤药理作用研究多以细胞模型作为研究对象,对于其药理作用、药效研究的评价还不够系统;对皂角刺抗肿瘤作用机制的研究仅涉及蛋白组学研究,且研究较为单一,未深入到基因转录水平。
By searching the related literature about the chemical constituents,pharmacological effects and pharmacodynamics research of Gleditsiae spina,this paper sorts out and makes a brief summary on the antineoplastic pharmacological effects and chemical constituents thereof,so as to provide references for further study on the antineoplastic pharmacological effects of Gleditsiae spina.Through the summary,it is found that the antineoplastic pharmacological effects of Gleditsiae spina mostly take cell model as the research object,and the evaluation of its pharmacological effects and pharmacodynamics research is not systematic enough;the research on the antineoplastic mechanism of Gleditsiae spina only involves proteomics research,moreover,the research is relatively simple,and does not go deep into the level of gene transcription.