文献类型：期刊文献

英文题名：Drosophila as a Model to Study the Mechanism of Nociception

作者：He, Jianzheng[1,2];Li, Botong[1,2];Han, Shuzhen[1,2];Zhang, Yuan[1,2];Liu, Kai[4];Yi, Simeng[5];Liu, Yongqi[1,3];Xiu, Minghui[1,3,6]

第一作者：和建政;何建政

通信作者：Liu, YQ[1];Xiu, MH[1];Liu, YQ[2];Xiu, MH[2];Xiu, MH[3]

机构：[1]Gansu Univ Chinese Med, Prov Level Key Lab Mol Med Major Dis & Prevent &, Lanzhou, Peoples R China;[2]Gansu Univ Chinese Med, Coll Basic Med, Lanzhou, Peoples R China;[3]Gansu Univ Chinese Med, Key Lab Transfer Dunhuang Med Prov & Ministerial, Lanzhou, Peoples R China;[4]Gansu Univ Chinese Med, Coll Integrated Tradit Chinese & Western Med, Lanzhou, Peoples R China;[5]China Agr Univ, Coll Anim Sci & Technol, State Key Lab Anim Nutr, Beijing, Peoples R China;[6]Gansu Univ Chinese Med, Coll Publ Hlth, Lanzhou, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Prov Level Key Lab Mol Med Major Dis & Prevent &, Lanzhou, Peoples R China;[2]corresponding author), Gansu Univ Chinese Med, Key Lab Transfer Dunhuang Med Prov & Ministerial, Lanzhou, Peoples R China;[3]corresponding author), Gansu Univ Chinese Med, Coll Publ Hlth, Lanzhou, Peoples R China.|[10735e9d5e7087247e71b]甘肃中医药大学公共卫生学院;[10735]甘肃中医药大学;

年份：2022

卷号：13

外文期刊名：FRONTIERS IN PHYSIOLOGY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000783550800001)】；

基金：This work received financial support from the National Natural Science Foundation of China (Nos. 82104562 and 82004228), "Double First Class" Scientific Research Key Project in Gansu (No. GSSYLXM-05), and Gansu Planning Projects on Science and Technology (No. 20JR10RA332).

语种：英文

外文关键词：nociception; conserved genetics; nociceptive sensory neurons; behavioral assay; Drosophila melanogaster

摘要：Nociception refers to the process of encoding and processing noxious stimuli, which allow animals to detect and avoid potentially harmful stimuli. Several types of stimuli can trigger nociceptive sensory transduction, including thermal, noxious chemicals, and harsh mechanical stimulation that depend on the corresponding nociceptors. In view of the high evolutionary conservation of the mechanisms that govern nociception from Drosophila melanogaster to mammals, investigation in the fruit fly Drosophila help us understand how the sensory nervous system works and what happen in nociception. Here, we present an overview of currently identified conserved genetics of nociception, the nociceptive sensory neurons responsible for detecting noxious stimuli, and various assays for evaluating different nociception. Finally, we cover development of anti-pain drug using fly model. These comparisons illustrate the value of using Drosophila as model for uncovering nociception mechanisms, which are essential for identifying new treatment goals and developing novel analgesics that are applicable to human health.