文献类型：期刊文献

中文题名：中医药调控Wnt信号通路的文献计量学分析

英文题名：Bibliometric Analysis of Traditional Chinese Medicine Regulating Wnt Signaling Pathway

作者：冉立成[1];袁艺[1];尚辉[1];陈丽荣[1];杨通[1];李磊[1];王亚军[1]

第一作者：冉立成

机构：[1]甘肃中医药大学针灸推拿学院,兰州730000

第一机构：甘肃中医药大学针灸推拿学院

年份：2024

卷号：26

期号：5

起止页码：1361

中文期刊名：世界科学技术-中医药现代化

外文期刊名：Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

收录：CSTPCD;;北大核心:【北大核心2023】；CSCD:【CSCD_E2023_2024】；

基金：国家自然科学基金委员会地区项目(82160936):基于Wnt、Notch信号通路的串话探讨针刺对抑郁模型大鼠海马神经干细胞再生的作用机制,负责人:王亚军;甘肃中医药大学“岐黄英才”导师专项基金项目(3016190125):艾灸“足三里”穴对骨髓抑制小鼠骨髓细胞中Wnt5a、Frizzled2、β-catenin分子影响的实验研究,负责人:王亚军

语种：中文

中文关键词：中医药;Wnt信号通路;文献计量学;Citespace;Vosviewer

外文关键词：Chinese medicine;Wnt signaling pathway;Bibliometrics;Citespace;Vosviewer

摘要：目的基于文献计量学分析国内外中医药调控Wnt信号通路防治疾病的研究概况、热点方向与前沿趋势。方法基于Citespace与Vosviewer文献计量软件对中国知网数据库(CNKI)及科学核心集数据库(WoSCC)中关于中医药调控Wnt信号通路的中、英文文献进行可视化分析。结果截止2023年4月中、英文各发表607篇与257篇相关文献,从2008年开始该领域文献发表数量呈波动性递增趋势;中国是发文最多的国家;广州中医药大学与湖南中医药大学为中文数据库发文最多的机构,上海中医药大学为英文文献库发文最多的机构;结合各学术团队的研究方向、关键词聚类及关键词突现梳理出中医药调控Wnt信号通路的研究热点聚焦在骨质疏松症、骨关节炎及肾纤维化等疾病中,胃癌、乳腺癌等疾病成为近几年新兴的研究方向。中药复方是中医药调控Wnt信号通路的主要干预方法,针刺、电针、瘢痕灸等中医药特色疗法成为近几年该领域的前沿热点。结论近年来中医药靶向Wnt信号通路防治疾病发展迅速,各专家团队获得丰富的研究成果,研究热点呈现多样化趋势,对此深入探索可为中医药治疗多种疾病的分子机制提供有力证据。
Objective To analyze the research status,hot directions and frontier trends of traditional Chinese medicine in the prevention and treatment of diseases by regulating Wnt signaling pathway based on bibliometrics.Methods Based on Citespace and Vosviewer bibliometric software,the literature on the regulation of Wnt signaling pathway by traditional Chinese medicine in CNKI and WoSCC was visually analyzed.Results As of April 2023,607 and 257 related literatures were published in Chinese and English respectively.Since 2008,the number of literatures published in this field has shown a fluctuating increasing trend.China is the country with the most publications;guangzhou University of Traditional Chinese Medicine and Hunan University of Traditional Chinese Medicine were the institutions with the most publications in the Chinese database,and Shanghai University of Traditional Chinese Medicine was the institution with the most publications in the English literature database.Combined with the research direction of each research team and keyword clustering and burst analysis,the research hotspots of traditional Chinese medicine regulating Wnt signaling pathway are focused on osteoporosis,osteoarthritis and renal fibrosis.Diseases such as gastric cancer and breast cancer have become emerging research directions in recent years.Electroacupuncture therapy to promote stem cell proliferation and treat neurological diseases is one of the frontier research trends in this field.The mechanism of traditional Chinese medicine regulating the interaction between Wnt and NF-kappaB signaling pathway to prevent and treat diseases has great research potential.Conclusion In recent years,the prevention and treatment of diseases by traditional Chinese medicine targeting Wnt signaling pathway has developed rapidly.Various expert teams have obtained rich research results,and the research hotspots show a diversified trend.In-depth exploration of this can provide strong evidence for the molecular mechanism of traditional Chinese medicine in the treatment of various diseases.