文献类型：期刊文献

英文题名：Efficacy and safety of Chinese herbal acupoint application for post-stroke sleep disorders: a systematic review and meta-analysis

作者：Xu, Yujing[1];Xia, Yuanjing[2];Wang, Xiaoyu[1];Qian, Xianxian[1];Xiang, Yue[1];Wei, Tanfang[3];Fu, Zhongxia[3]

第一作者：Xu, Yujing

通信作者：Fu, ZX[1]

机构：[1]Gansu Univ Chinese Med, Sch Nursing, Lanzhou, Peoples R China;[2]Northwest Minzu Univ, Sch Nursing, Lanzhou, Peoples R China;[3]Gansu Prov Matern & Child Hlth Care Hosp, Gansu Prov Cent Hosp, Dept Neurol, Lanzhou, Peoples R China

第一机构：甘肃中医药大学护理学院

通信机构：[1]corresponding author), Gansu Prov Matern & Child Hlth Care Hosp, Gansu Prov Cent Hosp, Dept Neurol, Lanzhou, Peoples R China.

年份：2026

卷号：17

外文期刊名：FRONTIERS IN NEUROLOGY

收录：;Scopus(收录号：2-s2.0-105051674145);WOS:【SCI-EXPANDED(收录号:WOS:001884806500001)】；

基金：The author(s) declared that financial support was received for this work and/or its publication. This work was supported by the Gansu Provincial Health Industry Research Project (GAWSHL2024-38) and the Research Fund of Gansu Provincial Maternity and Child Health Care Hospital (Gansu Provincial Central Hospital) (GMCCH2024-4-8). The funders had no role in the design of the systematic review, literature search and screening, data extraction, risk-of-bias assessment, statistical analysis, interpretation of results, manuscript preparation, or decision to submit the article.

语种：英文

外文关键词：acupoint application; meta-analysis; post-stroke insomnia; sleep disorders; stroke; systematic review; traditional Chinese medicine

摘要：Objective To evaluate the efficacy and safety of Chinese herbal acupoint application for post-stroke sleep disorders, particularly insomnia and poor sleep quality, and to provide evidence for sleep management during post-stroke rehabilitation. Methods This systematic review and meta-analysis followed the PRISMA 2020 reporting guideline and was registered in PROSPERO (CRD420261358357). China National Knowledge Infrastructure, Wanfang Data, VIP Database, Chinese Biomedical Literature Database (SinoMed), PubMed, the Cochrane Library, Embase, and Web of Science were searched from inception to April 1, 2026. Randomized controlled trials comparing acupoint application plus a comparator intervention with the same comparator intervention alone were included. Two reviewers independently screened studies and extracted data. Risk of bias was assessed using the original Cochrane Risk of Bias tool (RoB 1), certainty of evidence was evaluated using GRADE, and meta-analyses were performed in RevMan 5.4.1. Results Seven randomized controlled trials involving 608 participants were included. Compared with the matched comparator intervention alone, adjunctive acupoint application was associated with a higher trial-defined clinical response rate [odds ratio (OR) = 3.50, 95% confidence interval (CI) 2.05-5.97; p < 0.00001] and lower Pittsburgh Sleep Quality Index scores [mean difference (MD) = -2.69, 95% CI - 3.84 to -1.55; p < 0.00001], Hamilton Anxiety Rating Scale scores (MD = -9.38, 95% CI - 10.09 to -8.68; p < 0.00001), and Hamilton Depression Rating Scale scores (MD = -7.58, 95% CI - 9.08 to -6.08; p < 0.00001). Only two studies reported adverse events, and no study reported post-treatment follow-up. The certainty of evidence was low for trial-defined clinical response and very low for the other outcomes. Conclusion Low- to very-low-certainty evidence suggests that adjunctive Chinese herbal acupoint application may improve subjective sleep quality and emotional symptoms after stroke. However, the true effects may differ substantially from the pooled estimates. Current evidence is insufficient to establish safety or sustained benefit; larger, multicenter, rigorously designed trials are required. Systematic review registration https://www.crd.york.ac.uk/prospero/, CRD420261358357