文献类型：期刊文献

英文题名：Exosomal miRNAs as Biomarkers of Cancer: a Meta-Analysis

作者：Yang, Bo[1,2,3];Xiong, Wan-Yuan[3];Hou, Huai-Ding[3];Xu, Qian[4];Cai, Xiao-Ling[1];Zeng, Tong-Xu[5];Ha, Xiao-Qin[1,2]

第一作者：Yang, Bo

通信作者：Ha, XQ[1];Ha, XQ[2]

机构：[1]Lanzhou Univ, Hosp 2, Lanzhou, Gansu, Peoples R China;[2]Lanzhou Mil Area Command, Lanzhou Gen Hosp, Dept Clin Lab, Lanzhou, Gansu, Peoples R China;[3]Gansu Univ Chinese Med, Sch Clin Med, Lanzhou, Gansu, Peoples R China;[4]Xinzhou Peoples Hosp, Dept Clin Lab, Xingzhou, Peoples R China;[5]Second Peoples Hosp Lanzhou City, Lanzhou, Gansu, Peoples R China

第一机构：Lanzhou Univ, Hosp 2, Lanzhou, Gansu, Peoples R China

通信机构：[1]corresponding author), Lanzhou Univ, Hosp 2, Lanzhou, Gansu, Peoples R China;[2]corresponding author), Lanzhou Mil Area Command, Lanzhou Gen Hosp, Dept Clin Lab, Lanzhou, Gansu, Peoples R China.

年份：2019

卷号：65

期号：5

起止页码：789

外文期刊名：CLINICAL LABORATORY

收录：;Scopus(收录号：2-s2.0-85066506653);WOS:【SCI-EXPANDED(收录号:WOS:000468526200015)】；

基金：Gansu Provincial Key Research and Development Program NO: 17YF1FA135.

语种：英文

外文关键词：exosome; microRNA; biomarker; cancer; meta-analysis

摘要：Background: Tumor-derived exosomal miRNAs secreted by cancer cells play significant roles in the pathological processes of cancer, but no systematic meta-analysis has focused on the diagnostic efficiency of exosomal miRNAs. This meta-analysis assessed the diagnostic value of circulating exosomal miRNA in cancer. Methods: Studies evaluating the diagnostic value of exosomal miRNA were identified in EMBASE, PubMed, Cochrane Library, and Web of Science up to August 1, 2018. The quality of each study was assessed according to the Quality Assessment of Diagnostic Accuracy Studies 2, and STATA 14.0 was used for the analyses. The true positive (TP), false positive (FP), true negative (TN), and false negative (FN) rates were extracted from each study to obtain the pooled sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and their 95% confidence intervals (CIs). Results: The meta-analysis included 16 studies with 1,591 patients. Five studies reported sensitivity values, and the pooled sensitivity was 0.86 (95% CI = 0.80 - 0.90, while 29 studies reported specificity values, and the pooled specificity was 0.89 (95% CI = 0.83 - 0.93). The pooled PLR was 7.8 (95% CI = 4.9 - 12.4), the pooled NLR was 0.16 (95% CI = 0.11 - 0.24), the pooled DOR was 48 (95% CI = 23 - 101), and the AUC was 0.94 (0.91 - 0.96). Conclusions: Our meta-analysis indicated that body fluid exosomal miRNAs are highly accurate for distinguishing patients from healthy individuals, and exosomal miRNAs have superior diagnostic value in plasma, prostate cancer patients, and non-Asian individuals.