文献类型：期刊文献

中文题名：微小RNA与炎症性肠病关系的研究进展

英文题名：Research progress on the relationship between microRNA and inflammatory bowel disease

作者：苏海霞[1];付兆媛(审校者)[2];钟建春[1]

第一作者：苏海霞

机构：[1]甘肃中医药大学,兰州730000;[2]甘肃中医药大学附属医院消化科

第一机构：甘肃中医药大学

年份：2021

卷号：29

期号：11

起止页码：828

中文期刊名：中国中西医结合消化杂志

外文期刊名：Chinese Journal of Integrated Traditional and Western Medicine on Digestion

收录：CSTPCD

基金：甘肃省兰州市城关区课题(No:2021JSCX0008);甘肃中医药大学附属医院院内基金(No:gzfy-2020-11)。

语种：中文

中文关键词：微小RNA;炎症性肠病;溃疡性结肠炎;克罗恩病;生物标志物

外文关键词：microRNA;inflammatory bowel disease;ulcerative colitis;Crohn disease;biomarkers

摘要：炎症性肠病(inflammatory bowel disease,IBD)包括溃疡性结肠炎(ulcerative colitis,UC)及克罗恩病(Crohn disease,CD),是一种累及回肠、直肠、结肠的慢性非特异性肠道炎症性疾病[1]。流行病学资料显示,IBD的发病率表现出整体上升的趋势,不同地区发病率也有差异[2-3]。欧美国家IBD发病率女性高于男性,而在亚洲国家的发病率男性高于女性。
The pathogenesis of inflammatory bowel disease is still unclear and its diagnosis is restricted by many factors.MicroRNA is a highly conserved non-coding single-stranded small molecule RNA.In recent years,many studies have shown that microRNA can affect the development of inflammatory bowel disease by regulating the intestinal immune system,intestinal mucosal barrier and intestinal microbiota.Meanwhile,microRNA has become a new marker in the diagnosis of inflammatory bowel disease.It also provides a new target and idea for its treatment.