文献类型：期刊文献

英文题名：Puncture frequency, coagulopathy, and liver injury as independent risk factors for bleeding in acute diquat poisoning after enhanced blood purification therapy

作者：Zhang, Ting[1];Liu, Ling[1];Wang, Weibin[2];Ma, Yanan[3];Shi, Jianling[3];Gu, Hua[3]

第一作者：Zhang, Ting

通信作者：Gu, H[1]

机构：[1]Gansu Prov Hosp TCM, Emergency Ctr, Lanzhou 730050, Gansu, Peoples R China;[2]Gansu Prov Hosp TCM, Dept Ultrasound, Lanzhou 730050, Gansu, Peoples R China;[3]Gansu Univ Chinese Med, Lanzhou Petrochem Gen Hosp, Affiliated Hosp 4, Emergency Dept, 733 Fuli West Rd, Lanzhou 730060, Gansu, Peoples R China

第一机构：Gansu Prov Hosp TCM, Emergency Ctr, Lanzhou 730050, Gansu, Peoples R China

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Lanzhou Petrochem Gen Hosp, Affiliated Hosp 4, Emergency Dept, 733 Fuli West Rd, Lanzhou 730060, Gansu, Peoples R China.|[10735]甘肃中医药大学;

年份：2025

卷号：17

期号：5

起止页码：3961

外文期刊名：AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001507204100007)】；

语种：英文

外文关键词：Acute diquat poisoning; intensive blood purification therapy; bleeding complications

摘要：Objective: To identify independent risk factors for bleeding and propose preventive strategies in acute diquat poisoning (ADP) patients undergoing enhanced blood purification therapy (EBPT). Methods: In this retrospective study, a total of 297 ADP patients (May 2022-April 2024) were categorized into a conventional treatment (n=124) and EBPT (n=173) groups according to their treatment regimens. Clinical data, coagulation/liver function, and bleeding events were compared between the two groups. Logistics regression analysis was applied to identify independent risk factors for bleeding. COX regression model was used to explore the risk factors affecting survival prognosis. Kaplan-Meier method was used to draw survival analysis curve. Results: The EBPT group had a significantly higher bleeding incidence (45.05% vs. 4.23%, P<0.05), predominantly at puncture sites. Independent bleeding risk factors included puncture frequency, degree of poisoning, prolonged prothrombin time (PT), activated partial thromboplastin time (APTT), white blood cell count (WBC), elevated alanine aminotransferase (ALT), and aspartate aminotransferase (AST) (P<0.05). Bleeding patients had a higher 28-day mortality rate (50.00% vs. 18.95%, P<0.05) and longer ICU stays. Cox analysis confirmed that ALT, puncture frequency, poisoning severity, and bleeding were significant survival predictors (P<0.05). Conclusion: EBPT increases bleeding risk in ADP patients, mainly due to procedural factors and organ dysfunction. Optimizing puncture techniques and closely monitoring coagulation and liver function may improve patient outcomes.