文献类型：期刊文献

英文题名：SLC25 family with energy metabolism and immunity in malignant tumors

作者：Zhang, Guiqian[1,2,3,4];Wang, Ning[1];Ma, Shixun[2,3,5];Wei, Zhenhong[4,5];Tao, Pengxian[1,2,3,5];Cai, Hui[1,2,3,5]

第一作者：Zhang, Guiqian

通信作者：Tao, PX[1];Cai, H[1];Tao, PX[2];Cai, H[2];Tao, PX[3];Cai, H[3];Tao, PX[4];Cai, H[4]

机构：[1]Gansu Univ Chinese Med, Clin Med Coll 1, Lanzhou, Peoples R China;[2]Gansu Prov Hosp, Key Lab Mol Diagnost & Precis Med Surg Oncol Gansu, Lanzhou, Peoples R China;[3]Gansu Prov Hosp, Gen Surg Clin Med Ctr, Lanzhou, Peoples R China;[4]Gansu Prov Hosp, Cadre Ward Gen Surg Dept, Lanzhou, Peoples R China;[5]Gansu Prov Hosp, NHC Key Lab Diag & Therapy Gastrointestinal Tumor, Lanzhou, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Clin Med Coll 1, Lanzhou, Peoples R China;[2]corresponding author), Gansu Prov Hosp, Key Lab Mol Diagnost & Precis Med Surg Oncol Gansu, Lanzhou, Peoples R China;[3]corresponding author), Gansu Prov Hosp, Gen Surg Clin Med Ctr, Lanzhou, Peoples R China;[4]corresponding author), Gansu Prov Hosp, NHC Key Lab Diag & Therapy Gastrointestinal Tumor, Lanzhou, Peoples R China.|[10735]甘肃中医药大学;

年份：2024

卷号：26

期号：1

起止页码：65

外文期刊名：ONCOLOGIE

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001114522900001)】；

基金：We would like to thank Key Laboratory of Molecular Diagnostics and Precision Medicine for Surgical Oncology in Gansu Province, and General Surgery Clinical Medical Center of Gansu Provincial Hospital for their contributions.

语种：英文

外文关键词：SLC25 family; energy metabolism; endoplasmic reticulum stress; inhibitors; immunity; cancer

摘要：Solute Carrier Family 25 (SLC25) is the largest family of mitochondrial membrane proteins in the human body, consisting of 53 members. Mitochondrial phosphate carriers (MPiC), cellular iron metabolism, voltage-dependent anion channels (VDAC), and oxidative phosphorylation in the SLC25 family play dominant roles in material transport, energy metabolism, etc. SLC25 family-related proteins are involved in the regulation of the progression of a variety of cancers, including colon, gastric, and lung cancers. In addition, the SLC25 family has been implicated in endoplasmic reticulum stress (ERS) and immunity. Since SLC25 family proteins are involved in cancer progression and are associated with endoplasmic reticulum stress and immunity, exploring inhibitors of SLC25 family-related proteins is essential. However, the exact mechanism of SLC25 family-related proteins involved in cancer, as well as potential targets and SLC25 inhibitors have not been reported in the literature. This article focuses on summarizing the relevance of the SLC25 family to cancer, ERS, and immunity. This review also provides a comprehensive overview of SLC25 family-related inhibitors.