文献类型：期刊文献

英文题名：Association of interleukin-10 gene promoter polymorphisms with recurrent pregnancy loss: a meta-analysis

作者：Gu, Chongjuan[1,2];Gong, Hongxia[3];Zhang, Zheng[4];Yang, Zhao[1,2];Ma, Yongxin[1,2]

第一作者：Gu, Chongjuan

通信作者：Ma, YX[1];Ma, YX[2]

机构：[1]Sichuan Univ, West China Hosp, Dept Med Genet, 1st Keyuan 4 Lu, Chengdu 610041, Peoples R China;[2]Sichuan Univ, West China Hosp, Div Human Morbid Genom, 1st Keyuan 4 Lu, Chengdu 610041, Peoples R China;[3]Gansu Univ Chinese Med, Prov Key Lab Mol Med Major Dis & Prevent & Treatm, Lanzhou, Peoples R China;[4]Third Mil Med Univ, Southwest Hosp, Dept Obstet & Gynecol, Reprod Med Ctr, Chongqing, Peoples R China

第一机构：Sichuan Univ, West China Hosp, Dept Med Genet, 1st Keyuan 4 Lu, Chengdu 610041, Peoples R China

通信机构：[1]corresponding author), Sichuan Univ, West China Hosp, Dept Med Genet, 1st Keyuan 4 Lu, Chengdu 610041, Peoples R China;[2]corresponding author), Sichuan Univ, West China Hosp, Div Human Morbid Genom, 1st Keyuan 4 Lu, Chengdu 610041, Peoples R China.

年份：2016

卷号：33

期号：7

起止页码：907

外文期刊名：JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

收录：;Scopus(收录号：2-s2.0-84962256687);WOS:【SCI-EXPANDED(收录号:WOS:000379256100011)】；

基金：This work was supported by the National Basic Research Program of China (973 Program, 2012CB947600) and the National Natural Science Foundation of China (31070676, 90919006, and 31300961). The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.

语种：英文

外文关键词：Gene polymorphism; Interleukin-10; Meta-analysis; Recurrent pregnancy loss

摘要：It has been reported single-nucleotide polymorphisms (SNPs) of the IL-10 promoter might be associated with the susceptibility to recurrent pregnancy loss (RPL). Owing to the inconclusive results, we conducted a meta-analysis to systematically summarize and clarify the association between the IL-10 promoter SNPs and RPL risk. A systematic search of studies on the association of the three SNPs with RPL was conducted in PubMed and Embase. Odds ratios (ORs) and 95 % confidence intervals (95 % CIs) were used to pool the effect size. Eleven case-control studies on rs1800896, seven studies on rs1800871, and eight studies on rs1800872 were included. A significant association was identified between IL-10 rs1800896 with RPL risk (G versus A: OR = 1.21, 95 % CI 1.09-1.35). No evidence of association was found between rs1800871 and RPL when restricted to those studies in Hardy-Weinberg equilibrium in controls (T versus C: OR = 1.25, 95 % CI 0.76-2.06). No statistical association was demonstrated between rs1800872 and RPL (C versus A: OR = 1.08, 95 % CI 0.83-1.42). IL-10 rs1800896 significantly increases the risk of RPL, while rs1800872 is not correlated with RPL risk. No significant association is demonstrated between rs1800871 and RPL risk but this requires further investigation.