文献类型：期刊文献

英文题名：Research progress on the antitumor effects of astragaloside IV

作者：Zhou, Ruixi[2];Guo, Tiankang[1];Li, Junliang[1,2,3]

第一作者：Zhou, Ruixi

通信作者：Li, JL[1]

机构：[1]Gansu Prov Hosp, Dept Gen Surg, Lanzhou 730030, Peoples R China;[2]Gansu Univ Chinese Med, Sch Clin Med 1, Lanzhou 730030, Peoples R China;[3]Lanzhou Univ, Sch Clin Med 1, Lanzhou 730030, Peoples R China

第一机构：Gansu Prov Hosp, Dept Gen Surg, Lanzhou 730030, Peoples R China

通信机构：[1]corresponding author), Gansu Prov Hosp, Dept Gen Surg, Lanzhou 730030, Peoples R China.

年份：2023

卷号：938

外文期刊名：EUROPEAN JOURNAL OF PHARMACOLOGY

收录：;Scopus(收录号：2-s2.0-85144588421);WOS:【SCI-EXPANDED(收录号:WOS:000896934200007)】；

基金：This work was supported by the Natural Science Foundation of Gansu Province (NO. 20JR10RA372), Health Industry Research Project of Gansu Province (GSWSKY-2019-03), Open Fund Project of Gansu Key Laboratory of Molecular Diagnosis and Precision Therapy of Surgical Oncology (2020GSZDSYS02), Scientific Research and Innovation Fund of Gansu University of Chinese Medicine (2020KCYB-7), Research project of Traditional Chinese Medicine of Gansu-Province (GZKP-2020-12) , Reform and practical exploration of the talent training model of "university-hospital co-construction" of education department of Gansu Province ((2021)5-6), Longyuan Youth Innovation and Entrepreneurship Talent Project (111266548053), The Lanzhou Science and Technology bureau particular project (2020-XG-3), and The 14th Five Year Plan of Education Science of Gansu Province (GS(2021)GHB1859).

语种：英文

外文关键词：Astragaloside IV; Macrophage; Epithelial-mesenchymal transition; Drug resistance; Sensitivity

摘要：One of the most important and effective components of Astragalus membranaceus is astragaloside IV (AS-IV), which can exert anti-tumor effects through various pathways. For instance, AS-IV exerts an anti-tumor effect by acting at the cellular level, regulating the phenotype switch of tumor-associated macrophages, or inhibiting the development of tumor cells. Furthermore, AS-IV inhibits tumor cell progression by enhancing its sensitivity to antitumor drugs or reversing the drug resistance of tumor cells. This article reviews the different mechanisms of AS-IV inhibition of epithelial-mesenchymal transition (EMT), migration, proliferation, and invasion of tumor cells, inducing apoptosis and improving the sensitivity of anti-tumor drugs. This review summarizes recent progress in the current research into AS-IV anti-tumor effect and provides insight on the next anti-tumor research of AS-IV.