文献类型：期刊文献

英文题名：The Role of IL-37 and IL-38 in Colorectal Cancer

作者：Dang, Jie[1];He, Zhiyun[2];Cui, Xiang[3];Fan, Jingchun[4];Hambly, David J.[5,6];Hambly, Brett D.[4];Li, Xun[2];Bao, Shisan[4]

第一作者：Dang, Jie

通信作者：Li, X[1];Bao, SS[2]

机构：[1]Lanzhou Univ, Child & Adolescent Hlth Management Ctr, Hosp 2, Lanzhou, Peoples R China;[2]Lanzhou Univ, Dept Gen Surg, Hosp 1, Lanzhou, Peoples R China;[3]Lanzhou Univ, Dept Gen Surg, Hosp 2, Lanzhou, Peoples R China;[4]Gansu Univ Chinese Med, Sch Publ Hlth, Dept Epidemiol & Evidence Based Med, Ctr Evidence Based Med, Lanzhou, Peoples R China;[5]Gold Coast Univ Hosp, Resident Training Program, Southport, Qld, Australia;[6]Torrens Univ Australia, Ctr Hlth Futures, Sydney, NSW, Australia

第一机构：Lanzhou Univ, Child & Adolescent Hlth Management Ctr, Hosp 2, Lanzhou, Peoples R China

通信机构：[1]corresponding author), Lanzhou Univ, Dept Gen Surg, Hosp 1, Lanzhou, Peoples R China;[2]corresponding author), Gansu Univ Chinese Med, Sch Publ Hlth, Dept Epidemiol & Evidence Based Med, Ctr Evidence Based Med, Lanzhou, Peoples R China.|[10735e9d5e7087247e71b]甘肃中医药大学公共卫生学院;[10735]甘肃中医药大学;

年份：2022

卷号：9

外文期刊名：FRONTIERS IN MEDICINE

收录：;Scopus(收录号：2-s2.0-85124709909);WOS:【SCI-EXPANDED(收录号:WOS:000759855900001)】；

语种：英文

外文关键词：IL-37; IL-38; colorectal cancer; TAM; TAN

摘要：Colorectal cancer (CRC) is a major killer. Dysregulation of IL-37 and IL-38, both anti-inflammatory cytokines, is observed in auto-immune diseases. The precise regulatory mechanisms of IL-37/IL-38 during the development of CRC remains unclear, but chronic intestinal inflammation is involved in the carcinogenesis of CRC. Constitutive production of colonic IL-37 and IL-38 is substantially reduced in CRC, consistent with an inverse correlation with CRC differentiation. Reduced colonic IL-37 and IL-38 is relating to CRC invasion and distant metastasis, suggesting a protective role for IL-38 within the tumor micro-environment. IL-38 is reduced in right-sided CRC compared to left-sided CRC, which is in line with multiple risk factors for right-sided CRC, including the embryonic development of the colon, and genetic differences in CRC between these two sides. Finally, colonic IL-37 and tumor associated neutrophils (TAN) seem to be independent biomarkers of prognostic value, whereas colonic IL-38 seems to be a reliable and independent biomarker in predicting the 5-year survival post-surgery in CRC. However, there is room for improvement in available studies, including the extension of these studies to different regions/countries incorporating different races, evaluation of the role of multi-drug resistance, and different subsets of CRC. It would be useful to determine the kinetics of circulating IL-38 and its relationship with drug resistance/targeted therapy. The measurement of colonic IL-38 at the molecular and cellular level is required to explore the contribution of IL-38 pathways during the development of CRC. These approaches could provide insight for the development of personalized medicine.