文献类型：期刊文献

英文题名：Cytoplasmic DNA and AIM2 inflammasome in RA: where they come from and where they go?

作者：Xu, Conghui[1];Jing, Weiyao[1];Liu, Cui[1];Yuan, Bo[2];Zhang, Xinghua[3];Liu, Limei[4];Zhang, Fengfan[5];Chen, Ping[5];Liu, Qiang[1];Wang, Haidong[5];Du, Xiaozheng[1]

第一作者：Xu, Conghui

通信作者：Du, XZ[1];Wang, HD[2]

机构：[1]Gansu Univ Chinese Med, Dept Acupuncture Moxibust & Tuina, Lanzhou, Peoples R China;[2]Gansu Univ Tradit Chinese Med TCM, Dept Acupuncture & Pain, Affiliated Hosp, Lanzhou, Peoples R China;[3]Gansu Prov Hosp Tradit Chinese Med, Dept Acupuncture, Lanzhou, Peoples R China;[4]Gansu Univ Tradit Chinese Med TCM, Dept Zhengs Acupuncture, Affiliated Hosp, Lanzhou, Peoples R China;[5]Gansu Prov Hosp Tradit Chinese Med TCM, Dept Rheumat & Bone Dis, Lanzhou, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Dept Acupuncture Moxibust & Tuina, Lanzhou, Peoples R China;[2]corresponding author), Gansu Prov Hosp Tradit Chinese Med TCM, Dept Rheumat & Bone Dis, Lanzhou, Peoples R China.|[10735]甘肃中医药大学;

年份：2024

卷号：15

外文期刊名：FRONTIERS IN IMMUNOLOGY

收录：;Scopus(收录号：2-s2.0-85207185731);WOS:【SCI-EXPANDED(收录号:WOS:001339066500001)】；

基金：The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by the National Natural Science Foundation of China (No. 82060891), Youth Science and Technology Fund (No.23JRRA1686), Project of Zheng's Acupuncture Academic Schools of Heritage Studio, Gansu Province, State Administration of TCM (No. 2305135901).

语种：英文

外文关键词：rheumatoid arthritis; AIM2; cytosolic DNA; pyroptosis; inflammasome

摘要：Rheumatoid arthritis is a chronic autoimmune disease of undetermined etiology characterized by symmetric synovitis with predominantly destructive and multiple joint inflammation. Cytoplasmic DNA sensors that recognize protein molecules that are not themselves or abnormal dsDNA fragments play an integral role in the generation and perpetuation of autoimmune diseases by activating different signaling pathways and triggering innate immune signaling pathways and host defenses. Among them, melanoma deficiency factor 2 (AIM2) recognizes damaged DNA and double-stranded DNA and binds to them to further assemble inflammasome, initiating the innate immune response and participating in the pathophysiological process of rheumatoid arthritis. In this article, we review the research progress on the source of cytoplasmic DNA, the mechanism of assembly and activation of AIM2 inflammasome, and the related roles of other cytoplasmic DNA sensors in rheumatoid arthritis.