文献类型：期刊文献

英文题名：Epigenetic crosstalk between stem cells and tumors: mechanisms and emerging perspectives

作者：Zhou, Wenli[1];Liu, Xuehai[1];Li, Zhaoyu[2];Jia, Binkui[1];Lei, Xilin[1];Sun, Kai[3];Yang, Pengfei[1];He, Shiye[1];Wang, Di[4];Zhang, Haoling[4];Wang, Sinong[1]

第一作者：周文丽

通信作者：Wang, SN[1];Wang, D[2];Zhang, HL[2]

机构：[1]Gansu Univ Chinese Med, Affiliated Hosp, Sch Clin Chinese Med, Lanzhou 730000, Gansu, Peoples R China;[2]Gansu Univ Chinese Med, Coll Acupuncture Moxibust & Tuina, Lanzhou 730000, Gansu, Peoples R China;[3]Henan Univ Chinese Med, Coll Acupuncture Moxibust & Tuina, 156 Jinshui East Rd, Zhengzhou 450000, Henan, Peoples R China;[4]Univ Sains Malaysia, Adv Med & Dent Inst, Dept Biomed Sci, George Town 13200, Malaysia

第一机构：甘肃中医药大学第二附属医院

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Affiliated Hosp, Sch Clin Chinese Med, Lanzhou 730000, Gansu, Peoples R China;[2]corresponding author), Univ Sains Malaysia, Adv Med & Dent Inst, Dept Biomed Sci, George Town 13200, Malaysia.|[10735b845793de6ae2b30]甘肃中医药大学第二附属医院;[10735]甘肃中医药大学;

年份：2025

卷号：14

期号：3

起止页码：98

外文期刊名：AMERICAN JOURNAL OF STEM CELLS

收录：WOS:【ESCI(收录号:WOS:001574483400002)】；

基金：The project title: Construction and Practice of the Theoretical System of "New Blood Syndrome Theory" for Psoriasis, Key Special Project of "Research on Modernization of Traditional Chinese Medicine" under the National Key Research and Development Program, 2023-ZD-219. Gansu Province University Teachers' Innovation Fund Project (2025A-110) in 2025.

语种：英文

外文关键词：Stem cells; epigenetics; crosstalk mechanisms; DNA methylation; histone modification; non-coding RNA

摘要：Stem cells possess self-renewal and multipotent differentiation capabilities, exhibiting broad applications in regenerative medicine and tissue homeostasis maintenance. Their fate regulation relies heavily on precise epigenetic mechanisms. Cancer stem cells (CSCs), as key drivers of tumor heterogeneity, recurrence, and drug resistance, share extensive epigenetic features with normal stem cells, forming a complex and dynamic regulatory network. Mechanisms including DNA methylation, histone modification, chromatin remodeling, and ncRNAs collectively sustain stem cell pluripotency and tumor stemness, while aberrant epigenetic alterations serve as core drivers of tumor initiation and progression. In recent years, with the advent of single-cell omics and CRISPR-dCas9 epigenetic editing technologies, epigenetic "crosstalk" between stem cells and tumor cells has been progressively uncovered, especially the multidimensional epigenetic reprogramming induced by the tumor microenvironment (TME) that promotes CSC traits and drug resistance. This review systematically summarizes the epigenetic regulatory mechanisms of stem cells, epigenetic abnormalities in tumors, their interactions, and translational potential in therapeutic strategies, focusing on frontier topics such as reversible epigenetic plasticity, metabolic-epigenetic interplay, and liquid biopsy epigenetic biomarkers. Looking forward, artificial intelligence (AI) and big data analysis are expected to deepen the understanding of epigenetic heterogeneity, driving integrative innovations in precision medicine and regenerative interventions. Comprehensive understanding of the epigenetic crosstalk between stem cells and tumors will provide solid theoretical support and technical pathways for CSC-targeted therapies, epigenetic drug development, and stem cell fate manipulation.