文献类型：期刊文献

英文题名：ALK-positive inflammatory myofibroblastic tumor in the pelvis of a child: a case report and literature review

作者：Yang, Lei[1];Yan, Zhiheng[2]

第一作者：杨丽;杨力;杨玲;杨乐

通信作者：Yan, ZH[1]

机构：[1]Gansu Univ Chinese Med, Clin Med Coll 1, Lanzhou, Gansu, Peoples R China;[2]Gansu Prov Cent Hosp, Dept Ultrasound, Lanzhou, Gansu, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Prov Cent Hosp, Dept Ultrasound, Lanzhou, Gansu, Peoples R China.

年份：2026

卷号：16

外文期刊名：FRONTIERS IN ONCOLOGY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001678444100001)】；

基金：The author(s) declared that financial support was received for this work and/or its publication. Supported by the Natural Science Foundation of Gansu Province (Grant No. 2023-27, Project No. 23JRR A1747): "Correlation Study between SWE and Tumor Hypoxia and Histological Biomarkers in Breast Cancer".

语种：英文

外文关键词：ALK; case report; inflammatory myofibroblastic tumor; pediatric; pelvis

摘要：Inflammatory myofibroblastic tumor (IMT) is a rare neoplasm that primarily affects children and young adults. While typically found in the lungs, liver, and gastrointestinal tract, pelvic involvement is recognized but occurs less frequently than intra-abdominal IMT, particularly in pediatric patients. Here we report a case of a 2-year-old boy who presented with a brief history of vomiting and decreased appetite. Imaging revealed a cystic-solid mass in the pelvis with progressive enhancement of the solid component, leading to suspicion of a vascular soft tissue neoplasm. Surgical exploration identified a free-floating mass within the abdominal cavity supported by a long vascular pedicle originating from the splenic hilum, an atypical anatomical finding that added complexity to preoperative diagnosis. Complete surgical resection was performed, and postoperative examination was conducted. Histopathological analysis confirmed IMT, and fluorescence in situ hybridization (FISH) detected ALK gene rearrangement, which supported diagnostic confirmation of IMT in this case rather than guiding therapeutic intervention. The patient recovered uneventfully following surgery, with no evidence of recurrence during follow-up. This case supports considering IMT in pediatric pelvic masses and reinforces that complete surgical resection remains the primary treatment. Although ALK gene rearrangement was not associated with therapeutic intervention in the present case, its identification remains diagnostically relevant and may provide important insights into management decisions in selected clinical scenarios, such as recurrence or unresectable disease.