文献类型：期刊文献

英文题名：Integrin β3: structural functions, tumour microenvironment regulatory roles and targeted intervention strategies

作者：Peng, Lianyi[1];Liu, Fuxian[2];Yang, Yue[1];Zhang, Liying[3];Huang, Shuangsheng[1];Zhao, Fei[1];Li, Caili[1];Huang, Jiyu[1];Wang, Zihan[1];He, Jianxin[3]

第一作者：Peng, Lianyi

通信作者：Yang, Y[1];He, JX[2]

机构：[1]Northwest Univ Nationalities, Key Lab Environm Ecol & Populat Hlth Northwest Min, State Ethn Affairs Commiss, Lanzhou, Gansu, Peoples R China;[2]Yunnan Univ Tradit Chinese Med, Kunming, Yunnan, Peoples R China;[3]Gansu Univ Chinese Med, Key Lab Minist Educ Dunhuang Med & Transformat, Lanzhou, Gansu, Peoples R China

第一机构：Northwest Univ Nationalities, Key Lab Environm Ecol & Populat Hlth Northwest Min, State Ethn Affairs Commiss, Lanzhou, Gansu, Peoples R China

通信机构：[1]corresponding author), Northwest Univ Nationalities, Key Lab Environm Ecol & Populat Hlth Northwest Min, State Ethn Affairs Commiss, Lanzhou, Gansu, Peoples R China;[2]corresponding author), Gansu Univ Chinese Med, Key Lab Minist Educ Dunhuang Med & Transformat, Lanzhou, Gansu, Peoples R China.|[10735]甘肃中医药大学;

年份：2026

卷号：17

起止页码：1804949

外文期刊名：FRONTIERS IN IMMUNOLOGY

收录：;Scopus(收录号：2-s2.0-105035818783);WOS:【SCI-EXPANDED(收录号:WOS:001739560300001)】；

基金：The author(s) declared that financial support was received for this work and/or its publication. The Central University Basic Research Operating Fund Special Project (31920250061), the Talent Introduction Research Fund of Northwest Minzu University (xbmyjrc202235), the Science and Technology Project of Lanzhou City (2025-3-004), and the Open Fund of Dunhuang Medicine and Translational Medicine Key Laboratory (DYHX24-08) of this research project were funded by these sources.

语种：英文

外文关键词：angiogenesis; integrin beta 3 (ITGB3); targeted therapy; traditional Chinese medicine; tumour microenvironment

摘要：Integrin beta 3 (ITGB3) functions as a pivotal transmembrane receptor mediating bidirectional signalling between cells and the extracellular matrix within the tumour microenvironment (TME). Dysregulated ITGB3 expression activates downstream pathways such as FAK/PI3K-Akt/mTOR, orchestrating core malignant processes including invasion, metastasis, angiogenesis, immune evasion, and autophagy modulation. Beyond its mechanistic roles, ITGB3 serves as a valuable biomarker for early diagnosis and prognostic assessment. Therapeutic strategies targeting ITGB3 encompass small-molecule inhibitors, monoclonal antibodies, and emerging Traditional Chinese Medicine (TCM) formulations, which offer unique multi-component regulatory advantages. This review systematically elucidates the structure-function relationship of ITGB3, its multidimensional regulatory mechanisms in tumour progression, and current targeted intervention strategies. Ultimately, we aim to provide theoretical insights for establishing ITGB3-guided precision medicine and integrated treatment systems.