文献类型：期刊文献

中文题名：RNA结合基序蛋白15的功能及其在肿瘤中的研究进展

英文题名：Recent Advances in Unraveling the Functions of RBM15 and Its Significance in Tumorigenesis

作者：谈元郡[1];王霞[1];张百红[2];岳红云[3]

第一作者：谈元郡

机构：[1]甘肃中医药大学第一临床医学院,兰州730000;[2]中国人民解放军联勤保障部队第九四〇医院肿瘤科,兰州730050;[3]中国人民解放军联勤保障部队第九四〇医院眼科,兰州730050

第一机构：甘肃中医药大学临床医学院

年份：2023

卷号：44

期号：6

起止页码：739

中文期刊名：国际老年医学杂志

外文期刊名：International Journal of Geriatrics

收录：CSTPCD

基金：甘肃省自然科学基金项目(22JR5RA007)。

语种：中文

中文关键词：RNA结合基序蛋白15;肿瘤;mRNA;N6-甲基腺苷;

外文关键词：RNA binding motif protein 15;Tumor;mRNA;N6-methyladenosine

摘要：RNA结合基序蛋白15(RBM15)是一类有N端RNA识别基序(RRM)和C端Spen旁系/直系同源物(SPOC)结构的蛋白质。RBM15以N6-甲基腺苷(m6A)修饰依赖性方式或独立于m6A修饰的方式调节mRNA表达、神经干细胞分化、营养物质代谢和遗传稳态等过程。近年研究发现,RBM15与肿瘤发生发展密切相关。本文详细阐述了RBM15的功能,及其与多种肿瘤发生发展的关系,为临床上探讨靶向RBM15作为肿瘤治疗的新策略提供可靠依据。
RNA binding motif protein 15(RBM15)belongs to a class of proteins characterized by an N-terminal RNA recognition motif(RRM)and a C-terminal Spen paralog and ortholog C-terminal(SPOC)structure.RBM15 plays pivotal roles in modulating mRNA expression,guiding neural stem cell differentiation,regulating nutrient metabolism,and maintaining genetic homeostasis.Its influence on these cellular processes can either be dependent on N6-methyladenosine(m6A)modifications or occur independently of m6A.In recent years,RBM15 has emerged as a key player closely associated with tumorigenesis and developmental processes.This paper delves into intricate details regarding the multifaceted functions of RBM15 and its intricate interplay with the development of various tumors.These findings offer a robust foundation for the potential clinical exploitation of RBM15 as a novel therapeutic target in the fight against cancer.