文献类型：期刊文献

英文题名：Design, synthesis, and biological evaluation of bergapten derivatives as potent anti-pancreatic cancer agents

作者：Yue, Ying[1];Liu, Jia-Rong[2];Wang, Nan[3];Wang, Xing-Rong[4,5];Ma, Jun-Yi[1];Yang, Jun-Li[4,5]

第一作者：Yue, Ying

通信作者：Ma, JY[1];Yang, JL[2];Yang, JL[3]

机构：[1]Northwest Normal Univ, Coll Life Sci, 967 Anning East Rd, Lanzhou 730070, Peoples R China;[2]Northwest Minzu Univ, Dept Med, Lanzhou 730030, Peoples R China;[3]Gansu Univ Chinese Med, Coll Pharm, Lanzhou 730101, Peoples R China;[4]Chinese Acad Sci, Lanzhou Inst Chem Phys, CAS Key Lab Chem Northwestern Plant Resources, 18 Tianshui Middle Rd, Lanzhou 730000, Peoples R China;[5]Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Nat Med Gansu Prov, 18 Tianshui Middle Rd, Lanzhou 730000, Peoples R China

第一机构：Northwest Normal Univ, Coll Life Sci, 967 Anning East Rd, Lanzhou 730070, Peoples R China

通信机构：[1]corresponding author), Northwest Normal Univ, Coll Life Sci, 967 Anning East Rd, Lanzhou 730070, Peoples R China;[2]corresponding author), Chinese Acad Sci, Lanzhou Inst Chem Phys, CAS Key Lab Chem Northwestern Plant Resources, 18 Tianshui Middle Rd, Lanzhou 730000, Peoples R China;[3]corresponding author), Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Nat Med Gansu Prov, 18 Tianshui Middle Rd, Lanzhou 730000, Peoples R China.

年份：2025

外文期刊名：JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH

收录：;Scopus(收录号：2-s2.0-105008327024);WOS:【SCI-EXPANDED(收录号:WOS:001511198500001)】；

基金：This work was supported by grants from the National Natural Science Foundation of China (Grant No. 32161143019), International Partnership Program of Chinese Academy of Sciences (Grant No. E304G6GH), Science and Technology Program of Gansu Province (Grant No. 23ZDNA002, 23ZYQK0001, and 23JRRA623), and Science and Technology Program of Sichuan Province (Grant No. 2022YFN0019).

语种：英文

外文关键词：Bergapten derivatives; anti-pancreatic cancer; apoptosis; organoids; zebrafish

摘要：Bergapten, a natural product from Zanthoxylum bungeanum Maxim., exhibits anticancer, antibacterial, anti-inflammatory, and hypolipidemic effects. A derivative, FSG-Y5 showed potent activity against pancreatic cancer cells PANC-1 (IC50 = 2.31 +/- 0.25 mu M) and CFPAC-1 (IC50 = 4.41 +/- 0.47 mu M), inhibiting their survival, migration, and invasion while inducing apoptosis via Bax and Cleaved caspase-3 regulation. FSG-Y5 also suppressed pancreatic cancer organoids and zebrafish tumor growth in a concentration and time-dependent manner. These findings highlight bergapten derivatives as promising anticancer candidates, with FSG-Y5 as a potential anti-pancreatic cancer agent for further study.