文献类型：期刊文献

英文题名：A single-cell atlas of lung homeostasis reveals dynamic changes during development and aging

作者：Jia, Hao[1];Chang, Yuan[1];Chen, Yulin[1,2];Chen, Xiao[1];Zhang, Hang[1];Hua, Xiumeng[1];Xu, Mengda[1];Sheng, Yixuan[1];Zhang, Ningning[1];Cui, Hao[1];Han, Lei[1,3];Zhang, Jian[4];Fu, Xiaodong[5];Song, Jiangping[1]

第一作者：Jia, Hao

通信作者：Song, JP[1];Zhang, J[2];Fu, XD[3]

机构：[1]Chinese Acad Med Sci Peking Union Med Coll, Fuwai Hosp, Anim Expt Ctr, Natl Ctr Cardiovasc Dis,Beijing Key Lab Preclin Re, Beijing, Peoples R China;[2]Gansu Univ Chinese Med, Dept Tradit Chinese & Western Med, Lanzhou, Peoples R China;[3]Kunming Med Univ, Yanan Hosp, Dept Gen Surg, Kunming, Peoples R China;[4]Sun Yat Sen Univ, Affiliated Hosp 3, Thorac Surg Dept, Guangzhou, Peoples R China;[5]Guangzhou Med Univ, Guangzhou Inst Cardiovasc Dis, Dept Cardiol, Guangdong Key Lab Vasc Dis,Affiliated Hosp 2, Guangzhou, Peoples R China

第一机构：Chinese Acad Med Sci Peking Union Med Coll, Fuwai Hosp, Anim Expt Ctr, Natl Ctr Cardiovasc Dis,Beijing Key Lab Preclin Re, Beijing, Peoples R China

通信机构：[1]corresponding author), Chinese Acad Med Sci Peking Union Med Coll, Fuwai Hosp, Anim Expt Ctr, Natl Ctr Cardiovasc Dis,Beijing Key Lab Preclin Re, Beijing, Peoples R China;[2]corresponding author), Sun Yat Sen Univ, Affiliated Hosp 3, Thorac Surg Dept, Guangzhou, Peoples R China;[3]corresponding author), Guangzhou Med Univ, Guangzhou Inst Cardiovasc Dis, Dept Cardiol, Guangdong Key Lab Vasc Dis,Affiliated Hosp 2, Guangzhou, Peoples R China.

年份：2024

卷号：7

期号：1

起止页码：427

外文期刊名：COMMUNICATIONS BIOLOGY

收录：;Scopus(收录号：2-s2.0-85190349579);WOS:【SCI-EXPANDED(收录号:WOS:001198699900001)】；

基金：This work was supported by the National Natural Science Fund for Distinguished Young Scholars of China (82125004; to J.S.). Illustrations in Figs. 1a, 2a, 3a, 4a, d-f, 5c, g, i, 6a, 7a, d-i, 9g, and Supplementary Fig. 8e-g were created with BioRender.com (Invoice number 85D90E15-0005). Thanks to Yu Zhang (Ph.D. of Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College) for her suggestion on editing the main text for English language and grammar. Thanks to Yuanheng Huang (Ph.D. of the third affiliated hospital of Sun Yat-sen University, Sun Yat-sen University) for his contribution on clinical data collection.

语种：英文

摘要：Aging is a global challenge, marked in the lungs by function decline and structural disorders, which affects the health of the elderly population. To explore anti-aging strategies, we develop a dynamic atlas covering 45 cell types in human lungs, spanning from embryonic development to aging. We aim to apply the discoveries of lung's development to address aging-related issues. We observe that both epithelial and immune cells undergo a process of acquisition and loss of essential function as they transition from development to aging. During aging, we identify cellular phenotypic alternations that result in reduced pulmonary compliance and compromised immune homeostasis. Furthermore, we find a distinctive expression pattern of the ferritin light chain (FTL) gene, which increases during development but decreases in various types of lung cells during the aging process. The authors present a single-cell atlas of human lung samples comprising 45 cell types, which reveals dynamic transcriptional and phenotypic changes associated with development and aging.