文献类型：期刊文献

英文题名：MRI and PET/CT for evaluation of the pathological response to neoadjuvant chemotherapy in breast cancer: A systematic review and meta-analysis

作者：Li, Huimin[1,2];Yao, Liang[3];Jin, Penghui[4];Hu, Lidong[4];Li, Xiaofei[1];Guo, Tiankang[1];Yang, Kehu[5]

第一作者：Li, Huimin

通信作者：Guo, TK[1];Yang, KH[2]

机构：[1]Gansu Prov Peoples Hosp, Dept Gen Surg, Donggang West Rd, Lanzhou 730000, Gansu, Peoples R China;[2]Ningxia Med Univ, Sch Clin Med Sci, Shengli St, Yinchuan 750000, Peoples R China;[3]Hong Kong Baptist Univ, Clin Div, Hong Kong, Hong Kong, Peoples R China;[4]Gansu Univ Tradit Chinese Med, Sch Clin Med Sci, Lanzhou 730000, Gansu, Peoples R China;[5]Lanzhou Univ, Sch Basic Med Sci, Evidence Based Med Ctr, Lanzhou 730000, Gansu, Peoples R China

第一机构：Gansu Prov Peoples Hosp, Dept Gen Surg, Donggang West Rd, Lanzhou 730000, Gansu, Peoples R China

通信机构：[1]corresponding author), Gansu Prov Peoples Hosp, Dept Gen Surg, Donggang West Rd, Lanzhou 730000, Gansu, Peoples R China;[2]corresponding author), Lanzhou Univ, Sch Basic Med Sci, Evidence Based Med Ctr, Lanzhou 730000, Gansu, Peoples R China.

年份：2018

卷号：40

起止页码：106

外文期刊名：BREAST

收录：;Scopus(收录号：2-s2.0-85046776943);WOS:【SCI-EXPANDED(收录号:WOS:000438382800018)】；

语种：英文

外文关键词：MRI; PET/CT; Breast cancer; Neoadjuvant chemotherapy; Meta-analysis

摘要：Background: Neoadjuvant chemotherapy (NAC) has become an essential treatment for breast cancer. However, there is still no consensus on the best tool to evaluate pathological response to NAC. Methods: Two reviewers systematically searched Cochrane, PubMed, EMBASE, Web of Science, and CBM (last updated in February 2017) for eligible articles. We independently screened and selected studies that conformed to the inclusion criteria and extracted the requisite data. Pooled sensitivity, specificity, and the area under the SROC curve were calculated to estimate the diagnostic accuracy of magnetic resonance imaging (MRI) and positron emission computed tomography (PET/CT). And the relative DOR (RDOR) was used to compare accuracy for levels of the covariable. Results: Thirteen studies involving 575 patients who underwent MRI and 618 who underwent PET/CT were included in our analysis. The pooled sensitivity and specificity of MRI were 0.88 (95% CI: 0.78-0.94) and 0.69 (95% CI: 0.51-0.83), respectively. The corresponding values for PET/CT were 0.77 (95% CI: 0.58-0.90) and 0.78 (95% CI: 0.63-0.88), respectively. The area under the SROC curve for MRI and PET/CT were 0.88 and 0.84, respectively. And the RDOR = 1.44 (95% CI, 0.46-4.47 P = 0.83). Conclusion: MRI had a higher sensitivity and PET/CT had a higher specificity in predicting the pathologic response after NAC in patients with breast cancer. According to the area under the SROC curve and anatomic discriminative resolution, MRI is the more suitable recommendation for predicting the pathologic response after NAC. (c) 2018 Elsevier Ltd. All rights reserved.