文献类型：期刊文献

中文题名：中药对顺铂肝毒性的保护作用及其机制研究进展

英文题名：Mechanism of Chinese Medicine against Cisplatin-induced Hepatotoxicity:A Review

作者：张尚龙[1];连小龙[1];闫潇[1];张楠[1];叶礼巧[1];马趣环[1];邓毅[1,2]

第一作者：张尚龙

机构：[1]甘肃中医药大学,兰州730000;[2]甘肃省中药药理与毒理学重点实验室,兰州730000

第一机构：甘肃中医药大学

年份：2023

卷号：39

期号：8

起止页码：125

中文期刊名：中药药理与临床

外文期刊名：Pharmacology and Clinics of Chinese Materia Medica

收录：北大核心:【北大核心2020】；CSCD:【CSCD2023_2024】；

基金：国家自然科学基金(地区)项目(81960723);甘肃省中医药管理局(GZKP-2022-37);甘肃省自然科学基金项目(21JR11RA145);兰州市科技计划项目(2022-3-21)。

语种：中文

中文关键词：顺铂;肝毒性;中药复方;中药提取物;中药活性成分

外文关键词：Cisplatin;Hepatotoxicity;Chinese medicine extract;Chinese medicine compound;Active ingredients of Chinese medicine

摘要：顺铂为临床常用化疗药物之一,疗效显著且作用广泛,可治疗多种癌症。但顺铂在抗肿瘤的同时也对机体产生诸多毒性损伤,限制了其临床应用。近年来研究发现多数复方、中药提取物、活性成分具有抗炎及抗氧化等作用,对顺铂引起的机体损伤具有保护作用。然而其具体作用机制尚未完全明确。因此本文就复方、中药提取物及活性成分减轻或预防顺铂肝毒性损伤作用及其机制进行概述,为顺铂临床应用及肝损伤治疗药物的开发提供依据。
Cisplatin is one of the commonly used chemotherapeutic drugs,which has remarkable efficacy and extensive effects on a variety of cancers.However,it is toxic,which limits the clinical application.In recent years,it has been found that most Chinese medicine extracts,Chinese medicine compounds,and active ingredients of Chinese medicine have anti-inflammatory and antioxidant effects and have protective effect on cisplatin-induced injury.However,the specific mechanism is still unclear.Therefore,this paper summarizes the research on the effect and mechanism of Chinese medicine extracts,Chinese medicine compounds,and active ingredients of Chinese medicine in reducing or preventing cisplatin hepatotoxicity,which is expected to lay a basis for the clinical application of cisplatin and the development of drugs for the treatment of liver injury.