文献类型：期刊文献

中文题名：清热愈溃混悬剂对实验性胃溃疡大鼠的保护作用及机制研究

英文题名：Protective Effect of Qingreyukui Suspension against Experimental Gastric Ulcer in Rats

作者：杜玮泽[1,3];倪志涛[2];商婷[2];王谨慧[2];靳子明[2];史玉攀[2];李茂星[1,4]

第一作者：杜玮泽

机构：[1]甘肃中医药大学药学院,甘肃兰州730000;[2]甘肃中医药大学附属医院,甘肃兰州730000;[3]联勤保障部队第九四〇医院,甘肃兰州730050;[4]军事科学院军事医学研究院,北京100850

第一机构：甘肃中医药大学药学院（西北中藏药协同创新中心办公室）

年份：2022

卷号：35

期号：6

起止页码：511

中文期刊名：解放军药学学报

外文期刊名：Pharmaceutical Journal of Chinese People's Liberation Army

基金：甘肃省中医药管理局科研项目,No.GZK-2019-36;2020年中央高校创新团队项目,No.31920200010。

语种：中文

中文关键词：胃溃疡;清热愈溃混悬剂;炎症;氧化应激;大鼠

外文关键词：gastric ulcer;Qingreyukui suspension;inflammation;oxidative stress;rats

摘要：目的建立无水乙醇致大鼠急性胃溃疡模型,探讨清热愈溃混悬剂对实验性胃溃疡大鼠的保护作用。方法选取体质量均匀的SD大鼠随机分为正常对照组、模型对照组、阳性对照组与清热愈溃混悬剂低、中、高剂量组,每组8只。建立无水乙醇致大鼠实验性胃溃疡模型,评价口服给予清热愈溃混悬剂低、中、高剂量〔2.2、3.3、4.4 g·(kg·d)^(-1)〕对大鼠实验性胃溃疡的预防效果。结果与正常对照组比较,模型对照组大鼠胃黏膜表面出现大量淤血,上皮细胞脱落坏死,清热愈溃混悬剂可使大鼠胃黏膜溃疡面积显著减小;可明显降低大鼠胃组织中丙二醛、白介素-1β、白介素-6与肿瘤坏死因子-α水平(P<0.01);可升高胃组织中谷胱甘肽、超氧化物歧化酶与表皮生长因子水平(P<0.01)。结论清热愈溃混悬剂可通过抗氧化应激、抗炎症等作用对大鼠胃黏膜产生保护作用。
Objective To establish a model of acute gastric ulcer induced by anhydrous ethanol and to investigate the protective effect of Qingreyukui suspension.Methods SD rats of uniform body weight were randomly divided into the normal control group,model control group,positive control group〔Lansoprazole,30 mg·(kg·d)^(-1)〕,Qingreyukui suspension low-dose group,medium-dose group and high-dose group,with 8 rats in each.An experimental gastric ulcer model of rats was established via intragastric administration of 5 ml·kg^(-1)absolute ethanol.The preventive effect of Qingreyukui suspension at low,medium and high doses〔2.2,3.3,4.4 g·(kg·d)(-1)〕on experimental gastric ulcer in rats was evaluated.Results Compared with the normal group,the mucosal surface of rats in the model group showed a large amount of congestion,epithelial cells were exocytic and necrotic,and the mucosal ulcer area of these rats was significantly reduced.The levels of malondialdehyde,interleukin-1β,interleukin-6 and tumor necrosis factor-αin gastric tissues of rats were significantly decreased(P<0.01),while glutathione,superoxide dismutase and epidermal growth factors in gastric tissues were increased(P<0.01).Conclusion Qingreyukui suspension can significantly protect gastric mucosa in gastric ulcer rats by combating oxidative stress and inflammation.