文献类型：期刊文献

英文题名：The Critical Effect of Bile Acids in Atherosclerosis

作者：Qi, Shangwen[1];Luo, Xu[2];Liu, Shuangfang[1];Ling, Bishi[1];Jin, Hua[1]

第一作者：Qi, Shangwen

通信作者：Jin, H[1]

机构：[1]Gansu Univ Chinese Med, Clin Coll Chinese Med, 35 Dingxi East Rd, Lanzhou 730000, Gansu, Peoples R China;[2]Gansu Prov Canc Hosp, Dept Oncol, Lanzhou, Gansu, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Clin Coll Chinese Med, 35 Dingxi East Rd, Lanzhou 730000, Gansu, Peoples R China.|[10735]甘肃中医药大学;

年份：2022

卷号：80

期号：4

起止页码：562

外文期刊名：JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

收录：;Scopus(收录号：2-s2.0-85139378743);WOS:【SCI-EXPANDED(收录号:WOS:000864372400011)】；

基金：Supported by the National Natural Science Foundation of China, Grant/Award Numbers: 81860832, 82160886.

语种：英文

外文关键词：bile acids; farnesoid X receptor; G protein-coupled receptor 5; atherosclerosis; metabolic disorder

摘要：Atherosclerosis (AS) is one of the most common cardiovascular diseases and is the leading cause of arteriosclerotic cardiovascular disease. Bile acids are not only the products of cholesterol metabolism, but also an important class of signaling molecules. Bile acids exert their biological effects through the bile acid receptor signaling pathways. Bile acid receptors are widely distributed in human organs and tissues. The activation of transcriptional and signaling cascades controls bile acid metabolism and synthesis, lipid and carbohydrate metabolism, immune cell expression, and inflammatory responses. A large body of evidence indicates that bile acids play an important role in the initiation and development of AS, and are strongly associated with AS risk factors. The major bile acid receptors, nuclear receptor farnesoid X receptor (liver) and membrane receptor G protein-coupled receptor 5, exhibit anti-atherosclerotic effects. Other nuclear receptors exert different anti-atherosclerotic or pro-atherosclerotic effects. In this review, we summarize the current knowledge on the effects of bile acids and their receptors in AS and explore the pathway of bile acids involved in atherosclerotic lesions. The main research based on animal models or cell/tissue culture experiments is also discussed. This review provides new ideas for the development of novel therapeutic approaches for AS prevention and treatment.