文献类型：期刊文献

英文题名：The multiple roles of macrophages in peritoneal adhesion

作者：Yang, Shangwei[1];Zheng, Yanhe[2];Pu, Zhenjun[1];Nian, Hongyu[1];Li, Junliang[1,3]

第一作者：Yang, Shangwei

通信作者：Li, JL[1]

机构：[1]Gansu Univ Chinese Med, Lanzhou, Peoples R China;[2]Lanzhou New Area, Digest Dept, Peoples Hosp 1, Lanzhou, Peoples R China;[3]Gansu Prov Hosp, Dept Gen Surg, Lanzhou, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Prov Hosp, Dept Gen Surg, 204 Donggang West Rd, Lanzhou 730030, Gansu, Peoples R China.

年份：2024

外文期刊名：IMMUNOLOGY AND CELL BIOLOGY

收录：;Scopus(收录号：2-s2.0-85207910818);WOS:【SCI-EXPANDED(收录号:WOS:001344643200001)】；

基金：This research was supported by the non-profit Central Research Institute Fund of the Chinese Academy of Medical Sciences (NHCDP2022028), Key Laboratory of Molecular Diagnostics and Precision Medicine for Surgical Oncology in Gansu Province (2020GSZDSYS02), the Research Fund project of Gansu Provincial Hospital (22GSSYC-1, 22GSSYB-14) and Key Laboratory of Dunhuang Medicine, Ministry of Education (DHYX22-02).

语种：英文

外文关键词：Fibrosis; inflammatory reaction; macrophage; peritoneal adhesion; peritoneal repair

摘要：Peritoneal adhesion (PA) refers to the abnormal adhesion of the peritoneum either with the peritoneum itself or with tissues and organs that is caused by abdominopelvic surgery, abdominal infection or peritoneal inflammation. PA is associated with various clinical complications, such as abdominal pain and distension, intestinal obstruction, gastrointestinal disorders and female infertility, and adversely affects the quality of life of patients. Macrophages are essential for PA formation and can undergo polarization into classically activated macrophages (M1) and alternatively activated macrophages (M2), which are influenced by the peritoneal microenvironment. By releasing proinflammatory cytokines and reactive oxygen species, M1 macrophages promote peritoneal inflammatory reactions and the resultant formation of adhesion. In contrast, M2 macrophages secrete anti-inflammatory cytokines and growth factors to inhibit PA formation and to promote repair and healing of peritoneal tissues, and thereby play a significant anti-inflammatory role. This review comprehensively explores the function and mechanism of macrophages and their subtypes in PA formation to gain insight into the prevention and treatment of PA based on the modulation of macrophages.