文献类型：期刊文献

英文题名：Role and molecular mechanism of traditional Chinese medicine in preventing cardiotoxicity associated with chemoradiotherapy

作者：Lv, Xin-Fang[1,2,3];Wen, Ruo-Qing[1,2];Liu, Kai[1,2,3];Zhao, Xin-Ke[1,2,3];Pan, Chen-Liang[4];Gao, Xiang[1,2,3];Wu, Xue[1,2,5];Zhi, Xiao-Dong[1,2,3];Ren, Chun-Zhen[1,2];Chen, Qi-Lin[1,2];Lu, Wei-Jie[1,2];Bai, Ting-Yan[1,2];Li, Ying-Dong[1,2,3]

第一作者：Lv, Xin-Fang

通信作者：Li, YD[1];Li, YD[2];Li, YD[3]

机构：[1]Gansu Univ Chinese Med, Sch Tradit Chinese & Western Med, Lanzhou, Peoples R China;[2]Univ Hosp Gansu Tradit Chinese Med, Key Lab Prevent & Treatment Chron Dis Tradit Chine, Lanzhou, Peoples R China;[3]Gansu Univ Chinese Med, Affiliated Hosp, Lanzhou, Peoples R China;[4]Lanzhou Univ, Hosp 1, Lanzhou, Peoples R China;[5]Lanzhou Univ, Hosp 2, Lanzhou, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Sch Tradit Chinese & Western Med, Lanzhou, Peoples R China;[2]corresponding author), Univ Hosp Gansu Tradit Chinese Med, Key Lab Prevent & Treatment Chron Dis Tradit Chine, Lanzhou, Peoples R China;[3]corresponding author), Gansu Univ Chinese Med, Affiliated Hosp, Lanzhou, Peoples R China.|[10735b845793de6ae2b30]甘肃中医药大学第二附属医院;[10735]甘肃中医药大学;

年份：2022

卷号：9

外文期刊名：FRONTIERS IN CARDIOVASCULAR MEDICINE

收录：;Scopus(收录号：2-s2.0-85142292551);WOS:【SCI-EXPANDED(收录号:WOS:000888337200001)】；

基金：This work was partly supported by the National Natural Science Foundation of China (No. 81873132), the Science and Technology Innovation Project of Gansu Provincial Education Department (No. 2021jyjbgs-03), and the Gansu Provincial Scientific Research Project on Prevention and Treatment of Major Diseases in Traditional Chinese Medicine (No. GZKZD-2018-02).

语种：英文

外文关键词：cardio-oncology; cardiotoxicity; chemoradiotherapy; traditional Chinese medicine; pharmacology; alternative treatments

摘要：Cardiotoxicity is a serious complication of cancer therapy. It is the second leading cause of morbidity and mortality in cancer survivors and is associated with a variety of factors, including oxidative stress, inflammation, apoptosis, autophagy, endoplasmic reticulum stress, and abnormal myocardial energy metabolism. A number of studies have shown that traditional Chinese medicine (TCM) can mitigate chemoradiotherapy-associated cardiotoxicity via these pathways. Therefore, this study reviews the effects and molecular mechanisms of TCM on chemoradiotherapy-related cardiotoxicity. In this study, we searched PubMed for basic studies on the anti-cardiotoxicity of TCM in the past 5 years and summarized their results. Angelica Sinensis, Astragalus membranaceus Bunge, Danshinone IIA sulfonate sodium (STS), Astragaloside (AS), Resveratrol, Ginsenoside, Quercetin, Danggui Buxue Decoction (DBD), Shengxian decoction (SXT), Compound Danshen Dripping Pill (CDDP), Qishen Huanwu Capsule (QSHWC), Angelica Sinensis and Astragalus membranaceus Bunge Ultrafiltration Extract (AS-AM),Shenmai injection (SMI), Xinmailong (XML), and nearly 60 other herbs, herbal monomers, herbal soups and herbal compound preparations were found to be effective as complementary or alternative treatments. These preparations reduced chemoradiotherapy-induced cardiotoxicity through various pathways such as anti-oxidative stress, anti-inflammation, alleviating endoplasmic reticulum stress, regulation of apoptosis and autophagy, and improvement of myocardial energy metabolism. However, few clinical trials have been conducted on these therapies, and these trials can provide stronger evidence-based support for TCM.