文献类型：期刊文献

中文题名：肠道菌群与骨关节疾病的关系及中医药调节研究进展

英文题名：Relationship Between Intestinal Flora and Bone and Joint Diseases and Regulation of Traditional Chinese Medicine:A Review

作者：李辉[1];谢兴文[2];李宁[1];李建国[2];李鼎鹏[2];丁聚贤[2];柳博[2];罗鹏飞[1]

第一作者：李辉

机构：[1]甘肃中医药大学,兰州730000;[2]甘肃省第二人民医院,西北民族大学附属医院,兰州730030

第一机构：甘肃中医药大学

年份：2022

卷号：28

期号：7

起止页码：268

中文期刊名：中国实验方剂学杂志

外文期刊名：Chinese Journal of Experimental Traditional Medical Formulae

收录：CSTPCD;;北大核心:【北大核心2020】；CSCD:【CSCD2021_2022】；

基金：国家自然科学基金项目(81860864,82160911);中央引导地方科技发展专项(甘科资函[2020]60号);甘肃省科技计划资助项目(20JR5RA129);敦煌医学与转化教育部重点实验室开放课题项目(DHYX19-05);甘肃省中医药研究中心开放课题项目(ZYZX-2020-32);甘肃省第二人民医院院内重点项目(YNZD2021-2);中央高校基本科研业务费专项(31920210041)。

语种：中文

中文关键词：肠道菌群;中医药;骨质疏松;骨关节炎;类风湿;痛风

外文关键词：intestinal flora;traditional Chinese medicine;osteoporosis;osteoarthritis;rheumatoid;gout

摘要：肠道菌群是人体内最大的微生物库,由一千多种不同的物种组成,其结构和代谢产物随宿主年龄、饮食结构及肠道环境的变化而发生动态变化。研究表明,肠道微生物在调节人类众多生理病理过程中发挥关键作用,并且已被证明肠道菌群失衡可能是影响骨关节疾病发生发展的关键因素,这其中包括骨质疏松、骨关节炎、类风湿性关节炎、痛风性关节炎等几种常见的骨关节疾病。目前临床多使用降钙素、雌激素、非甾体抗炎药、免疫抑制剂、黄嘌呤氧化酶抑制剂等西药治疗上述相关骨关节疾病,但长期服用患者依从性差,胃肠道不良反应明显。中医药治疗骨关节疾病以其价廉、效优、不良反应小等占据重要治疗地位,并且具有多靶点、多机制、多层次的作用优势。近年来众多学者基于中医学肝肾理论,运用大量“补肝肾”“强筋骨”类中药治疗骨关节疾病进行了大量实验及临床研究,取得了可喜成果,但其作用机制尚未完全阐明。肠道菌群作为近年来医学研究领域的热点之一。研究发现,肠道菌群与骨关节疾病之间的关系密切。该文通过查阅国内外相关文献,发现中医药通过调节肠道菌群治疗骨关节疾病疗效显著,并且相关研究十分广泛。因此,笔者将近年来发表的相关文献进行整理,就肠道菌群与骨关节疾病的关系及中药活性成分和中药复方干预肠道菌群的研究进展做一综述,以期为中医药防治骨与关节疾病提供参考和依据。
Intestinal flora is the largest microbial community in human body,which consists of more than 1000 species.Its structure and metabolites change dynamically with the age,diet and intestinal environment of the host.Study shows that the intestinal microbes play a pivotal role in regulating human physiological and pathological processes,and intestinal flora imbalance may be the key factors affecting the occurrence and development of bone and joint diseases,including osteoporosis,osteoarthritis,rheumatoid arthritis and gouty arthritis.At present,calcitonin,estrogen,nonsteroidal anti-inflammatory drugs,immunosuppressants,xanthine oxidase inhibitors and other western drugs are mostly used to treat the above diseases.However,long-term use of western drugs leads to poor compliance and obvious gastrointestinal adverse reactions among patients.Traditional Chinese medicine(TCM)predominates in the treatment of bone and joint diseases due to its low price,high efficacy and slight side effects,with the advantages of multi-targets,multimechanism and multi-levels.In recent years,many scholars have carried out experiments and clinical studies on the treatment of bone and joint diseases by TCMs on the basis of the liver and kidney theory such as"tonifying liver and kidney and strengthening muscles and bones".Gratifying results have been achieved.However,the mechanism of action has not been fully clarified.Intestinal flora becomes a hot spot in medical research,and a close relationship between intestinal flora and bone and joint diseases has been unveiled.Relevant literature in China and abroad showed that TCM has a significant effect on the treatment of bone and joint diseases by regulating intestinal flora.In this paper,the relationship between intestinal flora and bone and joint diseases was summarized and the intervention of TCM active ingredients and compounds on intestinal flora was reviewed to facilitate the prevention and treatment of bone and joint diseases by TCM.