文献类型：期刊文献

中文题名：基于肠-关节轴探讨中药干预强直性脊柱炎的研究现状

英文题名：A review of the current state of research on traditional chinese medicine interventions for ankylosing spondylitis based on the gut-joint axis

作者：宋静静[1];杨娟娟[1];李浩林[1];芦栋生[1];苏瑾[1];李永红[1];金芳梅[2];陈平[2];王海东[2]

第一作者：宋静静

机构：[1]甘肃中医药大学,甘肃兰州730000;[2]甘肃中医药大学第一附属医院,甘肃兰州730050

第一机构：甘肃中医药大学

年份：2026

卷号：42

期号：7

起止页码：1005

中文期刊名：中国临床药理学杂志

外文期刊名：The Chinese Journal of Clinical Pharmacology

收录：;北大核心:【北大核心2023】；

基金：甘肃省科技计划基金资助项目(23JRRA1535)。

语种：中文

中文关键词：中药;强直性脊柱炎;肠-关节轴;肠道菌群

外文关键词：Chinese medicine;ankylosing spondylitis;gut-joint axis;gut microbiota

摘要：强直性脊柱炎(AS)是一种以慢性腰背痛为主要临床表现的炎症性自身免疫性疾病。其发病因素复杂,具有家族聚集性,与遗传、免疫、微生物感染等因素相关。肠道作为人体重要的消化器官和免疫器官,定植于其中的微生物失调可通过“肠-关节轴”参与AS发病。因此,本文通过阐述“肠-关节轴”的基本内容及其与AS发生发展的关系,总结了中医药通过调节肠道微生物结构和优化微生物代谢,改善肠道通透性、激活肠道黏膜免疫系统治疗AS的最新研究报道。旨在为进一步研究中医药通过“肠-关节轴”治疗AS提供参考。
Ankylosing spondylitis(AS)is an inflammatory autoimmune disease characterised primarily by chronic lower back pain.Its aetiology is complex,with a tendency to run in families,and is associated with factors such as genetics,the immune system and microbial infections.As a vital digestive and immune organ,the gut harbours a diverse microbial community;an imbalance in this microbiota may contribute to the development of AS via the"gut-joint axis".Consequently,this paper elucidates the fundamental principles of the"gut-joint axis"and its relationship with the onset and progression of AS.It summarises the latest research findings on the use of traditional chinese medicine to treat AS by regulating the gut microbiome,optimising microbial metabolism,improving intestinal permeability,and activating the intestinal mucosal immune system.The aim is to provide a reference for further research into the treatment of AS using traditional chinese medicine via the"gut joint axis".