文献类型：期刊文献

英文题名：Risk factors and serum amino acid metabolic profiles of patients with type 1 diabetes and concomitant mild cognitive impairment: A cross-sectional study

作者：Zhang, Yujie[1,2];Yang, Xueni[1,2];Zhang, Yue[2,3];Shang, Mengmeng[1,2];Tian, Limin[4]

第一作者：张玉洁;Zhang, Yujie

通信作者：Tian, LM[1]

机构：[1]Gansu Univ Chinese Med, Sch Clin Med Coll 1, Lanzhou 730000, Gansu, Peoples R China;[2]Gansu Prov Hosp, Dept Endocrinol, Lanzhou 730000, Gansu, Peoples R China;[3]Lanzhou Univ, Sch Clin Med 1, Lanzhou 730000, Gansu, Peoples R China;[4]Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Dept Endocrinol, Chengdu 610072, Sichuan, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Dept Endocrinol, Chengdu 610072, Sichuan, Peoples R China.

年份：2026

卷号：40

期号：7

外文期刊名：JOURNAL OF DIABETES AND ITS COMPLICATIONS

收录：;Scopus(收录号：2-s2.0-105039335894);WOS:【SCI-EXPANDED(收录号:WOS:001781275100001)】；

基金：This research was funded by the National Natural Science Foundation of China (Grant/Award Number: 82470829) .

语种：英文

外文关键词：Type 1 diabetes; Mild cognitive impairment; Targeted metabolomics; Amino acid; Serum

摘要：Aims: Mild cognitive impairment (MCI) is one of the chronic complications of type 1 diabetes (T1DM). Alteration in amino acid metabolism is commonly observed in diseases associated with cognitive impairment, but its role in type 1 diabetes-associated mild cognitive impairment (T1DM-MCI) remains unclear. We aimed to explore the risk factors for T1DM-MCI and identify potential metabolites that can help determine the absence or presence of MCI in T1DM. Materials: This cross-sectional study enrolled 119 participants, comprising 39 with T1DM-MCI, 48 with T1DM and normal cognition (T1DM-NC), and 32 healthy controls. MCI was defined as a Montreal Cognitive Assessment (MoCA) score less than 26. Serum amino acid levels were analyzed using ultra-performance liquid chromatography-tandem mass spectrometry. Correlation and receiver operating characteristic (ROC) analyses were also conducted. Results: The mean age of participants was 36 years, and 44% of the participants were female. Among patients with T1DM, the median disease duration was 7 (range: 3-15) years. Logistic regression analysis revealed that older age (odds ratio [OR] = 1.060; P = 0.008) and lower educational level (OR = 0.851; P = 0.038) were significantly associated with the presence of T1DM-MCI. In addition, compared to the T1DM-NC group, seven metabolites were significantly downregulated in the T1DM-MCI group. L-Valine distinguished T1DM-MCI from T1DM-NC with moderate accuracy (sensitivity: 72.7%, specificity: 75.7%, area under the curve: 0.745, P < 0.001). Conclusions: Our results revealed that in adults with T1DM, MCI may be associated with alterations in amino acid metabolism, providing new insights into the pathogenesis of T1DM-MCI.