文献类型：期刊文献

中文题名：外泌体在胃癌中的研究进展

英文题名：Research Progress of Exosome in Gastric Cancer

作者：陈鑫[1,2];郑金平[3];李林俞[1,2];李红玲[2]

第一作者：陈鑫

机构：[1]甘肃中医药大学第一临床医学院,甘肃 兰州;[2]甘肃省人民医院肿瘤内科,甘肃 兰州;[3]宁夏石嘴山市第二人民医院神经外科,宁夏 石嘴山

第一机构：甘肃中医药大学临床医学院

年份：2022

卷号：12

期号：10

起止页码：9255

中文期刊名：临床医学进展

外文期刊名：Advances in Clinical Medicine

语种：中文

中文关键词：胃癌;外泌体;肿瘤微环境;MEK-ERK信号通路

摘要：外泌体是直径在30~150 nm的脂质双分子层的小囊泡,携带多种细胞相关特异性活性物质。在胃癌微环境中胃癌细胞分泌的外泌体参与肿瘤的生长,细胞增殖,细胞侵袭转移及血管生成等过程。已有研究表明胃癌细胞外泌体与巨噬细胞增殖、迁移密切相关。但缺氧条件下胃癌细胞外泌体诱导巨噬细胞极化的具体途径和机制尚不明确。本文就胃癌细胞外泌体内容物介导MEK-ERK信号通路对巨噬细胞极化表型的影响及研究进展进行综述,旨在探讨外泌体在胃癌治疗中的潜在价值,为胃癌的治疗提供新的靶点。
Exosomes are small vesicles of lipid bilayers with diameters ranging from 30 nm~150 nm, which carry a variety of cell-related specific active substances. Exosomes secreted by gastric cancer cells in the microenvironment of gastric cancer are involved in tumor growth, cell proliferation, cell inva-sion, metastasis, and angiogenesis. Previous studies have shown that gastric cancer exosomes are closely related to macrophage proliferation and migration. However, the specific pathway and mechanism of macrophage polarization induced by exosome in gastric cancer cells under hypoxia are still unclear. This article reviews the effect and research progress of MEK-ERK signaling path-way mediated by exosome contents of gastric cancer cells on the polarization phenotype of macro-phages, aiming to explore the potential value of exosome in the treatment of gastric cancer and provide new targets for the treatment of gastric cancer.