文献类型：期刊文献

英文题名：Injectable responsive hydrogel with synergistic antibacterial and anti-inflammatory properties for enhanced periodontitis treatment

作者：Li, Xinjie[1];Zhang, Zhidong[1];Yang, Xin[1,2];Yu, Mengyu[1];Tang, Yanjiao[1];Wei, Jinxian[1];Li, Zhige[1];Hai, Jun[3];Zhang, Baoping[1,4]

第一作者：Li, Xinjie

通信作者：Li, ZG[1];Zhang, BP[1];Hai, J[2];Zhang, BP[3]

机构：[1]Lanzhou Univ, Sch Hosp Stomatol, Lanzhou 730000, Peoples R China;[2]Gansu Univ Chinese Med, Dept Stomatol, Affiliated Hosp, Lanzhou 730000, Peoples R China;[3]Chinese Acad Sci, CAS Key Lab Chem Northwestern Plant Resources, Key Lab Nat Med Gansu Prov, Lanzhou Inst Chem Phys, Lanzhou 730000, Peoples R China;[4]Gansu Prov Key Lab Maxillofacial Reconstruct & Int, Lanzhou 730000, Peoples R China

第一机构：Lanzhou Univ, Sch Hosp Stomatol, Lanzhou 730000, Peoples R China

通信机构：[1]corresponding author), Lanzhou Univ, Sch Hosp Stomatol, Lanzhou 730000, Peoples R China;[2]corresponding author), Chinese Acad Sci, CAS Key Lab Chem Northwestern Plant Resources, Key Lab Nat Med Gansu Prov, Lanzhou Inst Chem Phys, Lanzhou 730000, Peoples R China;[3]corresponding author), Gansu Prov Key Lab Maxillofacial Reconstruct & Int, Lanzhou 730000, Peoples R China.

年份：2025

卷号：23

期号：1

外文期刊名：JOURNAL OF NANOBIOTECHNOLOGY

收录：;EI(收录号：20254019267456);Scopus(收录号：2-s2.0-105017415746);WOS:【SCI-EXPANDED(收录号:WOS:001581843300004)】；

基金：We thank all individuals who participated in this study.

语种：英文

外文关键词：Responsive hydrogel; Chronic periodontitis; Anti-bacteria; Anti-inflammation

摘要：Periodontitis is a chronic inflammatory disease driven by dysbiotic microbial biofilms and localized reactive oxygen species (ROS) accumulation, with inflammation management made challenging by recurrent infections from residual pathogenic bacteria in the periodontal pockets. To address this, we engineered an injectable pH-responsive hydrogel (MH@ZIF-8/CS/beta-GP) through the integration of minocycline hydrochloride (MH)-encapsulated zeolitic imidazolate framework-8 (ZIF-8) nanoparticles into a chitosan (CS) and beta-glycerophosphate (beta-GP) crosslinked matrix. The MH@ZIF-8 displayed broad-spectrum antimicrobial efficacy against key periodontal pathogens including Porphyromonas gingivalis (Pg), and Aggregatibacter actinomycetemcomitans (Aa), primarily attributed to the synergistic antimicrobial effects of Zn ions and MH. Additionally, MH@ZIF-8 effectively eliminated ROS by inhibiting the NLRP3/Caspase-1/IL-1 beta signaling pathway, demonstrating potent anti-inflammatory effect in lipopolysaccharide (LPS)-stimulated RAW264.7 cells. The MH@ZIF-8/CS/beta-GP hydrogel, which exhibited favored cytocompatibility with human gingival fibroblasts (HGFs), undergoed a rapid sol-gel transition and pH-responsive sustained-release drug delivery under the acidic conditions of periodontal pockets, effectively responding to periodontitis microenvironment. Meanwhile, this hydrogel effectively alleviated alveolar bone loss in vivo. Overall, the developed MH@ZIF-8/CS/beta-GP hydrogel presents a novel strategy for chronic periodontitis treatment and demonstrates promising clinical application potential.