详细信息
外泌体与肿瘤微环境的关系及其递呈非编码RNA对乳腺癌的影响 被引量:2
Relationship between exosomes and the tumour microenvironment and the impact of their delivery of non-coding RNAs on breast cancer
文献类型:期刊文献
中文题名:外泌体与肿瘤微环境的关系及其递呈非编码RNA对乳腺癌的影响
英文题名:Relationship between exosomes and the tumour microenvironment and the impact of their delivery of non-coding RNAs on breast cancer
作者:马学莉[1];王俊亮[1];孙娟霞[1];王婧瑞[1];陶蕊[1];于春[2];韩涛[1,3];兰咏梅[4]
第一作者:马学莉
机构:[1]甘肃中医药大学药学院,甘肃兰州730000;[2]甘肃中医药大学第一临床医学院,甘肃兰州730000;[3]甘肃省中药药理与毒理学重点实验室,甘肃兰州730000;[4]西北民族大学医学院,甘肃兰州730000
第一机构:甘肃中医药大学药学院(西北中藏药协同创新中心办公室)
年份:2025
卷号:41
期号:2
起止页码:279
中文期刊名:中国临床药理学杂志
外文期刊名:The Chinese Journal of Clinical Pharmacology
收录:;北大核心:【北大核心2023】;
基金:国家自然科学基金资助项目(82160853);甘肃省自然科学基金资助项目(21JR1RA264、23JRRA725)。
语种:中文
中文关键词:外泌体;肿瘤微环境;乳腺癌;微小RNA;长链非编码RNA;环状RNA
外文关键词:exosomes;tumour microenvironment;breast cancer;micro RNA;long non-coding RNA;circular RNA
摘要:乳腺癌的发生发展与其微环境的信息传递息息相关。外泌体作为一种新型的信息通讯工具,其递呈非编码RNA参与乳腺癌细胞的增殖、迁移、侵袭,肿瘤相关成纤维细胞生成,细胞周期、致癌基因的降解等过程。本文综述了外泌体与肿瘤微环境的关系及其递呈非编码RNA对乳腺癌的作用以及在临床的应用,以期为乳腺癌的生物学研究和治疗提供新的思路和策略。
The development of breast cancer is closely related to the information transfer in its microenvironment.As a novel information communication tool,exosomes present non-coding RNAs that are involved in breast cancer cell proliferation,migration,invasion,tumour-associated fibroblasts ogenesis,cell cycle,degradation of oncogenes,etc.This paper reviews the relationship between exosomes and the tumour microenvironment and the role of their presenting non-coding RNAs on breast cancer as well as their clinical applications in order to provide new ideas for biological research and therapeutic strategies.
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