文献类型：期刊文献

中文题名：大黄及有效成分治疗脂肪肝作用机制的研究进展

英文题名：Research Progress on Mechanism of Dahuang(大黄)and Its Active Components in the Treatment of Fatty Liver

作者：杨宗慧[1];陈红刚[1,4,5,6];赵文龙[1,4,5,6];段海婧[1,3,5,6];赵磊[1,2,5,6];晋玲[1,4,5,6];王倩[1,2];张金保[1,2,3,5,6]

第一作者：杨宗慧

机构：[1]甘肃中医药大学,兰州730000;[2]甘肃省道地药材质量标准化技术研究与推广工程实验室,兰州730000;[3]甘肃省中药药理与毒理学重点实验室,兰州730000;[4]甘肃省珍稀中药资源评价与保护利用工程研究中心,兰州730000;[5]陇药产业创新研究院,兰州730000;[6]西北中藏药省部共建协同创新中心,兰州730000

第一机构：甘肃中医药大学

年份：2025

卷号：41

期号：7

起止页码：113

中文期刊名：中药药理与临床

外文期刊名：Pharmacology and Clinics of Chinese Materia Medica

收录：;北大核心:【北大核心2023】；

基金：中国工程院院地合作重大项目(编号:GS2021ZDA06);甘肃省自然科学基金项目(编号:20JR10RA330);甘肃省道地药材质量标准化技术研究与推广工程实验室开放基金项目(编号:ddyc-2022-02);甘肃省中药药理与毒理学重点实验室开放基金项目(编号:ZDSYS-KJ-2018-007);甘肃中医药大学引进人才科研启动基金项目(编号:2016YJRC-03);甘肃省科技计划项目(编号:23CXNA0033)。

语种：中文

中文关键词：大黄;大黄素;大黄酸;大黄酚;脂肪肝;作用机制;保肝;降脂

外文关键词：Dahuang(大黄);Emodin;Rhein;Chrysophanol;Fatty liver;Mechanism of action;Hepatoprotective;Lipid-lowering

摘要：脂肪肝是由多种因素导致的肝细胞内大量脂肪堆积从而引起肝脏病理性改变的代谢性疾病。近年来,随着生活水平的提高及饮食结构的变化,脂肪肝发病率有逐渐增加的趋势,对人们的健康造成了严重威胁。中药在脂肪肝的防治方面有着显著的效果,且具有多成分、多途径和多靶点的特点,已成为该领域近年来的研究热点。大量研究表明大黄具有降脂、保肝护肝作用。然其相关成分及作用机制尚不完全清晰,故本文通过对大黄成分及其治疗脂肪肝的中英文文献进行系统分析,结果显示,大黄治疗脂肪肝的主要活性成分为大黄素、大黄酚、大黄酸等,其机制至少包括修复肝细胞损伤、减轻炎症反应、减轻氧化应激、调控脂质代谢、改善胰岛素抵抗等,可为大黄的进一步研究和应用提供思路和参考。
Fatty liver is a metabolic disease caused by a large amount of fat accumulation in liver cells caused by various factors,which leads to pathological changes in the liver.In recent years,with the improvement of living standards and changes in dietary structure,the incidence of fatty liver has gradually increased,which poses a serious threat to people's health.Traditional Chinese medicine has a remarkable effect on the prevention and treatment of fatty liver and has the characteristics of multi-component,multi-pathway,and multi-target,which has become a research hotspot in this field in recent years.A large number of studies have shown that Dahuang(大黄)has lipid-lowering and hepatoprotective effects.However,its related components and mechanism of action are not completely clarified.Therefore,this paper systematically analyzed the components of Dahuang and its treatment of fatty liver in Chinese and English literature.The results show that the main active components of Dahuang in the treatment of fatty liver are emodin,chrysophanol,rhein,etc.The mechanism includes repairing liver cell injury,reducing inflammatory response,reducing oxidative stress,regulating lipid metabolism,and improving insulin resistance,which can provide ideas and references for further research and application of Dahuang.