文献类型：期刊文献

中文题名：慢性阻塞性肺疾病危险因素的Meta分析

英文题名：A Meta-analysis of risk factors for chronic obstructive pulmonary disease

作者：马娇娇[1];夏晓黎[2];王亚锋[1];魏才杰[1];张宁[1]

第一作者：马娇娇

机构：[1]甘肃中医药大学,甘肃兰州730000;[2]甘肃中医药大学附属医院,甘肃兰州730000

第一机构：甘肃中医药大学

年份：2023

卷号：15

期号：2

起止页码：111

中文期刊名：中医临床研究

外文期刊名：Clinical Journal Of Chinese Medicine

基金：慢阻肺合并阻塞性睡眠呼吸暂停综合征危险因素相关性的分析(gzfy-2020-09);充分氧合下综合肺康复方案对老年COPD稳定期患者的临床疗效评价(2020-ZD-63);补肾健脾法联合抗阻训练干预老年肌少-骨质疏松症临床真实世界研究(G21cp-2022-19)。

语种：中文

中文关键词：慢性阻塞性肺疾病;危险因素;Meta分析

外文关键词：Chronic obstructive pulmonary disease;Risk factors;Meta-analysis

摘要：背景:慢性阻塞性肺疾病(Chronic Obstructive Pulmonary Disease,COPD)是医学界健康焦点,早期评估和干预相关危险素可以预防疾病进展和提高临床疗效。目的:了解与COPD发展相关的风险因素非常重要,是唯一能减轻全球负担的成本效益高的公共卫生干预策略。方法:系统检索PubMed、The Cochrane Library、EMbase、中国知网、维普、万方、中国生物医学文献中国数据库等,搜集有COPD的相关危险因素的研究,检索时限建库以来至2022年3月的病例对照研究。由2名研究者独立筛选文献,提取资料并进行偏倚风险评价,定量综合分析国内外有关COPD发病主要危险因素的研究结果,运用RevMan5.4进行一致性检验及合并OR值和95%CI计算。结果:共纳入8篇文献,Meta分析结果显示:烟龄>20年OR=1.88,95%CI(1.44~2.47);年龄OR=1.97,95%CI(1.08~3.59);吸烟OR=1.45,95%CI(1.20~1.75),身体质量指数OR=1.17,95%CI(0.53~2.61);反复呼吸道感染OR=2.32,95%CI(1.28~4.21);呼吸疾病家族史OR=4.86,95%CI(2.06~11.51);性别OR=1.05,95%CI(0.70~1.58);职业暴露OR=4.96,95%CI(0.90~27.43)。结论:男性、高龄、吸烟、职业暴露、身体质量指数(肥胖)、反复呼吸道感染、呼吸疾病家族史是目前人群COPD发病的危险因素。但受纳入研究数量和质量的限制,尚待更多大样本、高质量的研究进一步验证。
Background:Chronic obstructive pulmonary disease(COPD)is a significant health and economic burden in the AsiaPacific region and around the world,and it is the focus of the medical community.Early assessment and intervention of related risk factors can prevent disease progression and improve clinical outcomes.Objective:Understanding the risk factors associated with the development of COPD is important and represents the only cost-effective public health intervention strategy that can reduce the global burden.Methods:PubMed,The Cochrane Library,EMmbase,CNKI,VIP,Wangfang and SinoMed were systematically searched to collect studies on COPD-related risk factors,and the search period was limited to case-control studies from the database establishment to March 2022.Two researchers independently screened the literature,extracted the data,and assessed the risk of bias,and quantitatively and comprehensively analyzed the research results of the main risk factors for COPD at home and abroad.Conformance check and OR and 95%CI calculations are performed using RevMan 5.4.Results:A total of 8 literatures were included.Meta-analysis showed that OR=1.88,95%CI(1.44~2.47)for smoking age more than 20 years,OR=1.97,95%CI(1.08~3.59)for age;OR=1.45,95%CI(1.20~1.75)for smoking;OR=1.17,95%CI(0.53~2.61)for body mass index(BMI);OR=2.32,95%CI(1.28~4.21)for recurrent respiratory tract infection;OR=4.86,95%CI(2.06~11.51)for family history of respisatory diseases;OR=1.05,95%CI(0.70~1.58)for gender;OR=4.96,95%CI(0.90-27.43)for occupational exposure.Conclusion:Male,advanced age,smoking,smoking age of more than 20 years,occupational exposure,obesity,recurrent respiratory tract infection,and family history of respiratory diseases are the risk factors of COPD in the current population.However,due to the limitation of the quantity and quality of included studies,more large-sample,high-quality studies are yet to be further verified.