文献类型：期刊文献

英文题名：Effect of traditional Chinese medicine in osteosarcoma: Cross-interference of signaling pathways and potential therapeutic targets

作者：Liu, Yuezhen[1];Jiang, Bing[2];Li, Yanqiang[1];Zhang, Xiaoshou[1];Wang, Lijun[1];Yao, Yasai[1];Zhu, Baohong[1];Shi, Hengwei[3];Chai, Xiping[4];Hu, Xingrong[4];Zhang, Bangneng[4];Li, Hongzhuan[4,5]

第一作者：刘延祯

通信作者：Li, HZ[1]

机构：[1]Gansu Univ Tradit Chinese Med, Clin Coll Tradit Chinese Med, Lanzhou, Peoples R China;[2]Gansu Univ Tradit Chinese Med, Dept Integrated Chinese & Western Med, Lanzhou, Peoples R China;[3]Gansu Univ Tradit Chinese Med, Affiliated Hosp 2, Lanzhou, Peoples R China;[4]Gansu Prov Hosp Tradit Chinese Med, Lanzhou, Peoples R China;[5]Gansu Prov Hosp Tradit Chinese Med, 418 Gua Zhou St, Lanzhou 730010, Gansu, Peoples R China

第一机构：甘肃中医药大学中医临床学院

通信机构：[1]corresponding author), Gansu Prov Hosp Tradit Chinese Med, 418 Gua Zhou St, Lanzhou 730010, Gansu, Peoples R China.

年份：2024

卷号：103

期号：3

起止页码：E36467

外文期刊名：MEDICINE

收录：;Scopus(收录号：2-s2.0-85182827495);WOS:【SCI-EXPANDED(收录号:WOS:001145855300031)】；

基金：This study was supported by the Natural Science Foundation (no. 22JR5RA640 and 22JR5RA634), and the Key R&D programs (no. 21YF5FA025).

语种：英文

外文关键词：osteosarcoma; traditional Chinese medicine; signaling pathway; potential target; ferroptosis

摘要：Osteosarcoma (OS) has a high recurrence rate, disability rate, mortality and metastasis, it brings great economic burden and psychological pressure to patients, and then seriously affects the quality of life of patients. At present, the treatment methods of OS mainly include radiotherapy, chemotherapy, surgical therapy and neoadjuvant chemotherapy combined with limb salvage surgery. These treatment methods can relieve the clinical symptoms of patients to a certain extent, and also effectively reduce the disability rate, mortality and recurrence rate of OS patients. However, because metastasis of tumor cells leads to new complications, and OS cells become resistant with prolonged drug intervention, which reduces the sensitivity of OS cells to drugs, these treatments still have some limitations. More and more studies have shown that traditional Chinese medicine (TCM) has the characteristics of multiple targets and multiple pathways, and can play an important role in the development of OS through several key signaling pathways, including PI3K/AKT, Wnt/beta-catenin, tyrosine kinase/transcription factor 3 (JAK/STAT3), Notch, transforming growth factor-beta (TGF-beta)/Smad, nuclear transcription factor-kappa B (NF-kappa B), mitogen-activated protein kinase (MAPK), nuclear factor E2-related factor 2 (Nrf2), Hippo/YAP, OPG/RANK/RANKL, Hedgehog and so on. In this paper, the signaling pathways of cross-interference between active ingredients of TCM and OS were reviewed, and the development status of novel OS treatment was analyzed. The active ingredients in TCM can provide therapeutic benefits to patients by targeting the activity of signaling pathways. In addition, potential strategies for targeted therapy of OS by using ferroptosis were discussed. We hope to provide a unique insight for the in-depth research and clinical application of TCM in the fields of OS growth, metastasis and chemotherapy resistance by understanding the signaling crosstalk between active ingredients in TCM and OS.