文献类型：期刊文献

中文题名：脂代谢紊乱对2型糖尿病患者早期胰岛素分泌的影响

英文题名：Effects of dyslipidemia on early insulin secretion in patients with type 2 diabetes mellitus

作者：田景伦[1];周毛吉[2];何书经[1];李薇[1]

第一作者：田景伦

机构：[1]成都市温江区人民医院内分泌科,611130;[2]甘肃中医学院临床医疗系

第一机构：成都市温江区人民医院内分泌科,611130

年份：2008

卷号：16

期号：7

起止页码：391

中文期刊名：中国糖尿病杂志

外文期刊名：Chinese Journal of Diabetes

收录：CSTPCD;;北大核心:【北大核心2004】；CSCD:【CSCD_E2011_2012】；

语种：中文

中文关键词：糖尿病,2型;血脂异常;早期胰岛素分泌

外文关键词：Diabetes mellitus,type 2; Dyslipidemia; Early insulin secretion

摘要：目的了解脂代谢紊乱对2型糖尿病(T2DM)患者早期胰岛素分泌功能的影响。方法93例未经调脂和降糖治疗的新诊T2DM患者根据血脂水平分为正常血脂组(B组)、单纯TG升高组(C组)和混合血脂升高组(D组),20例体检正常者为健康对照组(A组),根据OGTT结果计算和分析早期胰岛素分泌指数ΔI30/ΔG30和HOMA-IR。结果各组之间ΔI30/ΔG30比较:B、C、D组与A组之间差异有统计学意义(P<0.01,P<0.05和P<0.05),C、D组与B组之间差异有统计学意义(P<0.05),C组与D组之间差异无统计学意义(P>0.05);各组之间HOMA-IR比较:B、C、D组与A组之间差异有统计学意义(P<0.05),D组与B组之间差异有统计学意义(P<0.01),C组与B组之间差异无统计学意义(P>0.05)。结论T2DM患者同时存在早期胰岛素分泌缺陷和胰岛素抵抗(IR),血脂异常与早期胰岛素分泌功能降低和IR相关。
Objective To investigate the effects of dyslipidemia on early insulin secretion in patients with type 2 diabetes mellitus（T2DM）. Methods 93 newly diagnosed T2DM patients without lipid-lowering and anti-hyperglycemic therapies were divided into 3 groups： normal lipids （group B） ,single high triglyceride （group C）, and high triglyceride and high total cholesterol with or without low HDL-cholesterol or high LDL-cholesterol （group D）. The 20 non-diabetic subjects with normal lipids were healthy control group（group A）. Early insulin secretion indexes （△I30/△G30 ） and insulin resistance indexes （HOMA-IR） were calculated from oral glucose tolerance test. Results Compared with group A,group B,C and D had a significantly lower △I30/△G30 （P〈0.01 ,〈0. 05 and〈0.05） and a higher HOMA-IR（all P〈0.05）. In contrast to group B,the group C and D had a significantly lower △I30/△G30 （both P〈0. 05） ,and the group D had a significantly higher HOMA-IR（P〈0.01） in T2DM groups. But no significant differences in the △I30/△G30 between group C and D,and in HOMA-IR between group B and C（both P〉0. 05）,were observed. Conclusions High triglyceride reduces early insulin secretion function and cholesterol abnormalities increase insulin resistance in T2DM.