文献类型：期刊文献

英文题名：Targeting inhibition of the inflammatory response: advances in the treatment of myocardial fibrosis with natural medicine and active ingredients

作者：Shu, Chang[1];Ren, Chunzhen[1];Chen, Qilin[1];Wang, Yanyun[2];Li, Ruochen[2];Zhang, Yue[2];Yang, Shuyu[2];Wang, Ci[2,3];Li, Yingdong[1]

第一作者：舒畅

通信作者：Li, YD[1]

机构：[1]Gansu Univ Chinese Med, Sch Tradit Chinese & Western Med, Lanzhou, Gansu, Peoples R China;[2]Tianjin Univ Tradit Chinese Med, Dept Tradit Chinese Med, Tianjin, Peoples R China;[3]Tianjin Univ Tradit Chinese Med, Teaching Hosp 1, Tianjin, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Sch Tradit Chinese & Western Med, Lanzhou, Gansu, Peoples R China.|[10735]甘肃中医药大学;

年份：2025

卷号：12

外文期刊名：FRONTIERS IN CARDIOVASCULAR MEDICINE

收录：;Scopus(收录号：2-s2.0-105014276561);WOS:【SCI-EXPANDED(收录号:WOS:001557367100001)】；

基金：We thank Yingdong Li for the critical reading of the manuscript. Figures 1-5 were created by Biorender (www.biorender.com), for which we are grateful.

语种：英文

外文关键词：myocardial fibrosis; inflammatory response; pathological mechanism; natural medicine; active ingredients

摘要：Myocardial fibrosis is a critical pathological foundation of cardiovascular diseases and a fundamental process underlying myocardial remodeling. The inflammatory response is a key driver of myocardial fibrosis, promoting the proliferation of myocardial fibroblasts and collagen deposition through the activation of multiple cytokines and signaling pathways. Natural medicines and active ingredients exhibit distinct therapeutic advantages characterized by not only potent pharmacological efficacy and favorable safety profiles, but also unique multi-target mechanisms of action that enable synergistic modulation of complex pathological pathways. These properties enable them to comprehensively modulate the inflammatory response, thereby providing novel therapeutic strategies for myocardial fibrosis. In this review, we explore the etiology of myocardial fibrosis and the mechanisms by which natural medicines and active ingredients inhibit the inflammatory response to treat myocardial fibrosis. We aim to provide a solid reference for future research on natural medicine-based therapies targeting the inflammatory pathways involved in myocardial fibrosis.