文献类型：期刊文献

英文题名：The induction and suppression of type I and type III interferons by human group H rotavirus

作者：Liu, Xin-yi[1,2];Wang, Ming-yue[1,2];Zhang, Qing[1];Kong, Xiang-yu[1];Wang, Hong[1];Li, Dan-di[1];Pang, Li-li[1,3];Duan, Zhao-jun[1,3]

第一作者：刘晓燕;刘芯宇;刘翔毅;刘熙钰;Liu, Xin-yi

通信作者：Pang, LL[1];Duan, ZJ[1];Pang, LL[2];Duan, ZJ[2]

机构：[1]China CDC, Natl Inst Viral Dis Control & Prevent, NHC Key Lab Med Virol & Viral Dis, Beijing 102206, Peoples R China;[2]Gansu Univ Chinese Med, Sch Publ Hlth, Lanzhou 730000, Peoples R China;[3]China CDC, Natl Inst Viral Dis Control & Prevent, Beijing 102206, Peoples R China

第一机构：China CDC, Natl Inst Viral Dis Control & Prevent, NHC Key Lab Med Virol & Viral Dis, Beijing 102206, Peoples R China

通信机构：[1]corresponding author), China CDC, Natl Inst Viral Dis Control & Prevent, NHC Key Lab Med Virol & Viral Dis, Beijing 102206, Peoples R China;[2]corresponding author), China CDC, Natl Inst Viral Dis Control & Prevent, Beijing 102206, Peoples R China.

年份：2023

卷号：581

起止页码：26

外文期刊名：VIROLOGY

收录：;Scopus(收录号：2-s2.0-85148772274);WOS:【SCI-EXPANDED(收录号:WOS:000948600800001)】；

基金：We thank Prof. Yi-xin Ji for her assistance with the design of primers and probes. This work was funded by the National Key Research and Development Program of China (2021YFC2301000) .

语种：英文

外文关键词：Group H Rotavirus; Interferon response; Type I interferon; Type III interferon; NSP1 protein

摘要：Group H Rotavirus (RVH) is associated with human diarrhea gastroenteritis. The interferon (IFN) response induced by RVH remains unclear. In this study, we first studied the characteristic feature of RVH and found J19 strain of RVH grew less efficiently compared with the G6P1 strain of RVA. Next, we found that infection with the J19 virus resulted in the secretion of IFN-lambda 1, but not IFN-beta, while both IFN-beta and IFN-lambda 1 could inhibit J19 replication significantly in Caco-2 cells. NSP1 played an important role in the suppression of type I and type III IFN response, and NSP5 protein significantly inhibited activation of IFN-lambda 1. J19 NSP1 suppressed the induction of IFN-beta obviously than G6P1 NSP1, while G6P1 NSP1 reduced IFN-lambda 1 induction to the greatest extent compared with G9P8, Wa, and J19 NSP1s. Our studies reveal the propagation feature of RVH and interferon induction and suppression by group H rotavirus.