文献类型：期刊文献

英文题名：The Role of PPARγ Gene Polymorphisms, Gut Microbiota in Type 2 Diabetes: Current Progress and Future Prospects

作者：Zhao, Yi-Kun[1];Zhu, Xiang-Dong[2];Liu, Rong[1];Yang, Xia[1];Liang, Yong-Lin[1,3];Wang, Yan[2,4]

第一作者：Zhao, Yi-Kun

通信作者：Liang, YL[1];Wang, Y[2]

机构：[1]Gansu Univ Chinese Med, Dept Basic Med Coll, Lanzhou, Peoples R China;[2]Ningxia Med Univ, Dept Tradit Chinese Med Coll, Yinchuan, Peoples R China;[3]Gansu Univ Chinese Med, 35 Dingxi East Rd, Lanzhou 730030, Gansu, Peoples R China;[4]Ningxia Med Univ, 1160 Shengli St, Yinchuan 750004, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, 35 Dingxi East Rd, Lanzhou 730030, Gansu, Peoples R China;[2]corresponding author), Ningxia Med Univ, 1160 Shengli St, Yinchuan 750004, Peoples R China.|[10735]甘肃中医药大学;

年份：2023

卷号：16

起止页码：3557

外文期刊名：DIABETES METABOLIC SYNDROME AND OBESITY

收录：;Scopus(收录号：2-s2.0-85176460031);WOS:【SCI-EXPANDED(收录号:WOS:001103037500001)】；

基金：Research on clinical application basic and transformation development of Shenqitangluo Pill in the treatment of type 2 diabetes based on quantity-effect relationship (2022BEG02034) and research on clinical application and transformation development of Dahuangtangluo Pill in the treatment of type 2 diabetes based on quantity-effect relationship (2021CYZC-03).

语种：英文

外文关键词：PPAR gamma; T2D; lipid metabolism; insulin resistance; gut microbiota

摘要：Over the past decade, there has been a significant increase in studies investigating the relationship between the polymorphisms of the Peroxisome Proliferator-Activated Receptor gamma (PPAR gamma) gene and Type 2 Diabetes (T2D). PPAR gamma, a critical transcription factor, plays a central role in lipid metabolism, insulin resistance, and inflammatory response. Concurrently, the influence of gut microbiota on the development of T2D has gained increasing attention, especially their role in affecting host metabolism, such as lipid metabolism and the PPAR gamma signaling pathway. This review provides a comprehensive analysis of recent studies on PPAR gamma gene polymorphisms and their association with T2D, with a specific emphasis on the implications of gut microbiota and their interaction with PPAR gamma pathways. We also discuss the potential of manipulating gut microbiota and targeting PPAR gamma gene polymorphisms in T2D management. By deepening our understanding of these relationships, we aim to pave the way for novel preventative and therapeutic strategies for T2D.