文献类型：期刊文献

中文题名：基于多指标权重分析结合正交设计优化大黄消痔栓粉碎工艺

英文题名：Optimization of Crushing Process for Dahuang Xiaozhi Suppositories Based on Multi index Weight Analysis and Orthogonal Design

作者：金月[1];王耀鹏[1];谢静[2];宋治荣[1];张磊[1];常登玺[1];常承东[1]

第一作者：金月

机构：[1]甘肃中医药大学附属医院,兰州730000;[2]嘉峪关市食品药品和医疗器械检验检测中心

第一机构：甘肃中医药大学第二附属医院

年份：2022

卷号：25

期号：9

起止页码：1541

中文期刊名：中国药师

外文期刊名：China Pharmacist

收录：CSTPCD

基金：甘肃省中医药管理局科研计划项目(编号:GZK-2018-12)。

语种：中文

中文关键词：大黄消痔栓;粉碎工艺;正交设计;层次分析法;权重赋权系数;AHP-CRITIC混合加权法;

外文关键词：Dahuang Xiaozhi suppositories;Crushing process;Orthogonal design;Analytic hierarchy process;CRITIC;AHP-CRITIC mixed weighting method;

摘要：目的:优化大黄消痔栓内容物的最佳粉碎工艺。方法:以总蒽醌、游离蒽醌、槐角苷、休止角、压缩度为评价指标,采用层次分析法、基于指标相关性的权重赋权系数(CRITIC)法及AHP-CRITIC混合加权法来确定复方中各指标的权重系数,结合正交试验设计法,考察投药量、投药细度、粉碎时间对大黄消痔栓内容物粉碎效果的影响,以L_(9)(3^(4))正交设计进行试验,优化大黄消痔栓粉碎工艺参数。结果:大黄消痔栓内容物的最佳粉碎工艺参数为投药500 g,投药细度为中粉,粉碎时间为30 min。结论:该粉碎工艺可行,能客观反映处方配伍信息,重复性好,可为大黄消痔栓的粉碎工艺优化提供参考。
Objective:To optimize the crushing process of the contents of Dahuang Xiaozhi suppositories.Methods:Taking total anthraquinone,free anthraquinone,sophoricoside,angle of repose and compressibility as the evaluation indexes,the weight coefficient of each index in the compound was determined by analytic hierarchy process,weight weighting coefficient(CRITIC)method based on index correlation and AHP-CRITIC mixed weighting method.Combined with orthogonal experimental design,the effects of dosage,fineness and crushing time on the crushing effect of the contents of Dahuang Xiaozhi suppositories were tested by L_(9)(3^(4))orthogonal design to optimize the crushing process parameters of Dahuang Xiaozhi suppositories.Results:The optimum crushing process parameters of the contents of Dahuang Xiaozhi suppositories were with dosage of 500 g,fineness of medium powder and crushing time of 30 min.Conclusion:The crushing process is feasible,which can objectively reflect the compatibility information of the prescription,and has good repeatability.It can provide reference for the optimization of the crushing process of Dahuang Xiaozhi suppositories.