文献类型：期刊文献

英文题名：Association of Depression with Long-Term Cardiovascular Risks in Older Patients with Obstructive Sleep Apnea

作者：Zhao, Zhe[1,2];Gao, Yinghui[3];Lin, Junling[4];Xu, Ruyi[5];He, Zijun[6];Zhao, Libo[1,2];Fang, Fengfeng[6];Cai, Weimeng[7];Chen, Kaibin[8];Fan, Li[1,2,9,10];Liu, Lin[7,10,11]

第一作者：Zhao, Zhe

通信作者：Fan, L[1];Liu, L[1];Liu, L[2]

机构：[1]Chinese Peoples Liberat Army Gen Hosp, Cardiol Dept, Med Ctr 2, Beijing, Peoples R China;[2]Chinese Peoples Liberat Army Gen Hosp, Natl Clin Res Ctr Geriatr Dis, Beijing, Peoples R China;[3]Peking Univ, Int Hosp, PKU UPenn Sleep Ctr, Beijing, Peoples R China;[4]Capital Med Univ, Beijing Chaoyang Hosp, Dept Pulm & Crit Care Med, Beijing, Peoples R China;[5]Chinese Peoples Liberat Army Gen Hosp, Med Ctr 6, Beijing, Peoples R China;[6]Yanan Univ, Med Coll, Yanan, Peoples R China;[7]Chinese Peoples Liberat Army Gen Hosp, Med Med Ctr 2, Dept Resp & Crit Care Med, Beijing, Peoples R China;[8]Gansu Univ Chinese Med, Sleep Ctr, Affiliated Hosp, Lanzhou, Peoples R China;[9]Chinese Peoples Liberat Army Gen Hosp, Cardiol Dept, Med Ctr 2, 28 Fuxing Rd, Beijing 100853, Peoples R China;[10]Chinese Peoples Liberat Army Gen Hosp, Natl Clin Res Ctr Geriatr Dis, 28 Fuxing Rd, Beijing 100853, Peoples R China;[11]Chinese Peoples Liberat Army Gen Hosp, Med Ctr 2, Dept Resp & Crit Care Med, 28 Fuxing Rd, Beijing 100853, Peoples R China

第一机构：Chinese Peoples Liberat Army Gen Hosp, Cardiol Dept, Med Ctr 2, Beijing, Peoples R China

通信机构：[1]corresponding author), Chinese Peoples Liberat Army Gen Hosp, Natl Clin Res Ctr Geriatr Dis, 28 Fuxing Rd, Beijing 100853, Peoples R China;[2]corresponding author), Chinese Peoples Liberat Army Gen Hosp, Med Ctr 2, Dept Resp & Crit Care Med, 28 Fuxing Rd, Beijing 100853, Peoples R China.

年份：2023

卷号：15

起止页码：1033

外文期刊名：NATURE AND SCIENCE OF SLEEP

收录：;Scopus(收录号：2-s2.0-85179307192);WOS:【SCI-EXPANDED(收录号:WOS:001118570200001)】；

基金：Master reports a grant from Army experimental animal special research project (SYDW_KY [2021] 04) , Military Health Care Project (23BJZ27, 22BJZ52, 19BJZ38) and Military Equipment Construction Application Research Project (LB20211A010013) .

语种：英文

外文关键词：obstructive sleep apnea; OSA; depression; major adverse cardiovascular events; MACE; older adults

摘要：Introduction: Obstructive sleep apnea (OSA) is associated with an increased risk of cardiovascular disease (CVD). Depression is a crucial factor among the various factors that are associated with OSA and CVD.Purpose: This study was conducted with an aim to assess the prognostic significance of depression on the MACE in older patients with OSA.Patients and Methods: 1106 older patients with OSA, without myocardial infarction (MI), history of hospitalization for unstable angina, or heart failure at baseline were enrolled and followed up prospectively. Incidence rates were expressed as cumulative incidence. Cox proportional hazards analysis was used to estimate the risk of all events. The primary outcomes were major adverse cardiovascular events (MACE). Each patient underwent polysomnography (PSG) and GDS-12 scale assessment. Those with an apnea-hypopnea index (AHI) greater than 5 were diagnosed with OSA, while those with a scale score greater than 3 were diagnosed with depression.Results: Among the 1106 older patients with OSA, depression was found in 133(12.0%) patients, 96(8.7%) patients experienced MACE during the follow-up. Depression was associated with a higher cumulative incidence of MACE in older patients with OSA. Multivariate analysis revealed that depression independently increased the risk of MACE (adjusted hazard ratio [aHR] = 2.29; 95% confidence interval [CI]: 1.34-3.90; P = 0.002). Subgroup analyses showed that male patients (aHR = 2.96; 95% CI: 1.52-5.77; P = 0.001), overweight-obese individuals (aHR = 2.98; 95% CI: 1.49-6.00; P = 0.002), and those with moderate-severe OSA (aHR = 2.82; 95% CI: 1.55-5.14; P = 0.001) and concurrent depression were at a higher risk for MACE.Conclusion: Depression is common in older patients with OSA in the absence of MI, hospitalization for unstable angina, or heart failure, and confers an independent, increased risk of MACE.