文献类型：期刊文献

英文题名：Effect of Sini San Freeze-dried powder on sleep-waking cycle in insomnia rats

作者：Yan, Xingke[1,2];Zhang, Zeguo[3];Xu, Fuju[3];Li, Yuefeng[3];Zhu, Tiantian[3];Ma, Chongbing[3];Liu, Anguo[3]

第一作者：严兴科;Yan, Xingke

通信作者：Li, YF[1]

机构：[1]Gansu Univ Tradit Chinese Med, Dept Acupuncture, Dept Pharm, Lanzhou 730020, Peoples R China;[2]Key Lab Pharmacol & Toxicol Tradit Chinese Med Ga, Lanzhou 730020, Peoples R China;[3]Gansu Univ Tradit Chinese Med, Dept Acupuncture, Lanzhou 730020, Peoples R China

第一机构：甘肃中医药大学药学院（西北中藏药协同创新中心办公室）

通信机构：[1]corresponding author), Gansu Univ Tradit Chinese Med, Lanzhou 730020, Peoples R China.|[10735]甘肃中医药大学;

年份：2014

卷号：34

期号：5

起止页码：572

外文期刊名：JOURNAL OF TRADITIONAL CHINESE MEDICINE

收录：MEDLINE(收录号：25417408);;Scopus(收录号：2-s2.0-84916638878);WOS:【SCI-EXPANDED(收录号:WOS:000343190500009)】；PubMed(收录号：25507136);

基金：Supported by Hippocampus Neural Coding Mechanism Research on Sini San Intervention Sleep Disorders of PTSD in Myospalax cansus from the National Natural Science Foundation (No. 81460611); Study on Sini San for regulation of expression of proteins of drosophila brain of sleep deprivation of Gansu Province Natural Science Foundation (No. 145RJZA076); Fundamental Research Funds for the Gansu Provincial Department of Finance Universities (No. 2013-2); Mechanisms of hippocampal neurons based on Jiawei Sini San intervention coding mode PTSD sleep disorders; Ministry of Education, Sini San for intervention of sleep deprivation in drosophila Based nano-2D-LC/MS technology of Science and Technology Key Project (No. 212186); Proteonnics and effective substance basic of Sini San for improving sleep of Gansu Province Natural Science Foundation (No. 1010RJZA212)

语种：英文

外文关键词：Sleep initiation and maintenance disorders; Electroencephalography; Sleep stages; Medicine, Chinese Traditional; Sini San

摘要：OBJECTIVE: To investigate the effects of the Sini San at different doses on each sleeping state [slow-wave sleep 1 (SWS1), slow-wave sleep 2 (SWS2), rapid-eye-movement (REM), wakefulness (W)] in insomnia rats and to identify its mode of action for improving sleep. METHODS: The insomnia rats were randomly divided into a high-, medium- or low-dose group of Sini San (equal to crude drug 8.8, 4.4, or 2.2 g/kg, respectively) for seven consecutive days. RESULTS: Compared with pre-administration, SWS2 was significantly increased after administration of the low dose. Compared with pre-administration, W was significantly decreased and SWS1, SWS2, and the total sleeping time (TST) were markedly increased after administration of the medium dose. Compared with pre-administration, W was significantly decreased and SWS1, SWS2, rapid-eye-movement sleep, and TST were significantly longer after administration of the high dose. The effects of Sini San on sleep-wake cycle are dose-dependent. CONCLUSION: The results suggest that Sini San extends SWS1 and SWS2, which increases the total sleeping time. (C) 2014 JTCM. All rights reserved.