文献类型：期刊文献

英文题名：A Case-Control Study of the Associations between EGLN1 Gene Polymorphisms and COPD

作者：Li, Xin[1];Zhang, Peng[1,2];Yu, Jing[1];Zhang, Chunyan[3];Shi, Yanli[3];Wei, Xueyan[3];Li, Honge[1];Zhang, Xuhui[4];Lin, Ao[5];Yang, Zhen[1];Wang, Yunchao[3];Wang, Xinhua[1]

第一作者：李忻;李欣

通信作者：Wang, XH[1];Wang, YC[2]

机构：[1]Gansu Univ Chinese Med, Lanzhou 730000, Gansu, Peoples R China;[2]Inner Mongolia Autonomous Reg Peoples Hosp, Alxa League, Inner Mongolia, Peoples R China;[3]Gansu Univ Chinese Med, Inst Basic Med, Inst Publ Hlth, Lanzhou 730000, Gansu, Peoples R China;[4]Gansu Univ Chinese Med, Dept Resp Med, Affiliated Hosp, Lanzhou 730000, Gansu, Peoples R China;[5]Guangzhou Med Univ, Affiliated Hosp 1, Inst Publ Hlth, State Key Lab Resp Dis, Guangzhou 510120, Guangdong, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Lanzhou 730000, Gansu, Peoples R China;[2]corresponding author), Gansu Univ Chinese Med, Inst Basic Med, Inst Publ Hlth, Lanzhou 730000, Gansu, Peoples R China.|[10735]甘肃中医药大学;

年份：2024

卷号：29

期号：1

外文期刊名：FRONTIERS IN BIOSCIENCE-LANDMARK

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001155765700010)】；

基金：This research was funded by the following grants: Fund project of Gansu Provincial Department of Education 2022CYZC-53 (Xinhua Wang) ; National Key Research and Development Program Project of Gansu Urban and Rural Natural Population Cohort Construction and Tumor Follow-up Research 2017YFC0907202 (Xinhua Wang) .

语种：英文

外文关键词：COPD; EGLN1; polymorphism; susceptibility

摘要：Background: Environmental and genetic factors are jointly involved in the development of chronic obstructive pulmonary disease (COPD). The EGLN1 gene is a major factor in upstream regulation of the hypoxia-inducible pathway. EGLN1 negatively regulates the hypoxia-inducible factors HIF-l alpha and HIF-2 alpha by regulating the concentration of oxygen, mainly in a hypoxic environment. Hypoxia is a common physiologic condition during the progression of COPD, and several studies have identified genetic variants in EGLN1 as a key factor in the adaptation to hypoxic environments. However, it is still unclear whether there is an association between EGLN1 variants and the risk of developing COPD. Methods: A case -control study was conducted in the Gannan Tibetan Autonomous Prefecture, Gansu Province. A total of 292 COPD patients and 297 healthy controls were enrolled to assess the association of EGLN1 single nucleotide polymorphisms (SNPs) (rs41303095 A>G, rs480902 C>T, rs12097901 C>G, rs2153364 G>A) with COPD susceptibility. Results: The EGLN1 rs41303095 A>G, rs480902 C>T, rs12097901 C>G, and rs2153364 G>A polymorphisms were not associated with COPD susceptibility (p > 0.05). Conclusions: The EGLN1 rs41303095 A>G, rs480902 C>T, rs12097901 C>G and rs2153364 G>A polymorphisms were found in this study not to be associated with susceptibility to COPD in Gannan Tibetans.